PMID: 6975270Feb 1, 1981Paper

C-19393 S2 and H2, new carbapenem antibiotics. IV. Inhibitory activity against beta-lactamases

The Journal of Antibiotics
K OkonogiM Kuno

Abstract

New carbapenem antibiotics, C-19393 S2 and H2, have been found to be potent and broad-spectrum inhibitors of beta-lactamases. Among 11 types of beta-lactamases tested, those from Escherichia coli (plasmid-bearing), Klebsiella pneumoniae, Proteus vulgaris, Serratia marcescens and Bacteroides fragilis were especially sensitive. They also inhibited cephalosporinases insensitive to clavulanic acid. The inhibition by C-19393 S2 and H2 was of progressive type, except for the inhibition of E. coli enzyme (plasmid-mediated type I) by C-19393 H2. The inhibition of E. coli beta-lactamase by C-19393 S2 was irreversible, while that by C-19393 H2 was reversible.

Citations

Jan 1, 1983·CRC Critical Reviews in Biochemistry·V S Rao, T K Vasudevan
Jan 1, 1988·Journal of Enzyme Inhibition·R B Silverman
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Malcolm G. P. Page
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·F KobayashiS Mitsuhashi

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