c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response

FEBS Letters
Ting SongHui Zhong

Abstract

The tyrosine kinase, c-Abl, plays important roles in many aspects of cellular function. Previous reports showed that c-Abl is involved in NF-kappaB signaling. However, the functions of c-Abl in innate immunity are still unknown. Here we demonstrate that the mitochondrial antiviral signaling (MAVS) protein can be physically associated with c-Abl in vivo and in vitro. MAVS interacted with c-Abl through its Card and TM domain. A phosphotyrosine-specific antibody indicated that MAVS was phosphorylated by c-Abl. Functional impairment of c-Abl attenuated MAVS or VSV induced type-I IFN production. Importantly, c-Abl knockdown in MCF7 cells displayed impaired MAVS-mediated NF-kappaB and IRF3 activation. Taken together, our results suggest that c-Abl modulates innate immune response through MAVS.

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Citations

Oct 15, 2013·Journal of Molecular Biology·Jana L Jacobs, Carolyn B Coyne
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Jan 20, 2021·Cellular & Molecular Immunology·Koji OnomotoMitsutoshi Yoneyama

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