C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production

Virology
Takayuki KomatsuBin Gotoh

Abstract

We here report a molecular basis for downregulation of interferon (IFN)-beta production by V and C proteins of Sendai virus (SeV). The infection of HeLa cells with SeV poorly induced IFN-beta even if the expression of C/C' was disrupted. In contrast, when the expression of C/C'/Y1/Y2 or V/W was disrupted, SeV infection strongly induced IFN-beta production and significantly activated the interferon regulatory factor (IRF)-3 pathway. The independent expression of C or V inhibited the double-stranded (ds) RNA- or Newcastle disease virus (NDV)-induced activation of IRF-3 and NF-kappa B, as well as the IFN-beta promoter. This inhibitory effect was also observed when Y1, Y2, or a C-terminal half fragment (aa 85-204) of C was independently expressed. Phosphorylation and homodimer formation of IRF-3 were suppressed not only in cells infected with SeV capable of expressing both C/C'/Y1/Y2 (or Y1/Y2) and V/W, but also in HeLa cells constitutively expressing Y1. These results suggest that C, Y1, Y2, and V block signaling pathways leading to IRF-3 activation to downregulate IFN-beta production.

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Citations

Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·J AndrejevaR E Randall
Aug 26, 2014·Trends in Immunology·Koji OnomotoTakashi Fujita
Dec 17, 2008·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Takemasa SakaguchiYoshiyuki Nagai
Aug 26, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stephen Goodbourn, Richard E Randall
Jan 27, 2005·Viral Immunology·Friedemann WeberOtto Haller
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mounira K Chelbi-AlixDanielle Blondel
Nov 9, 2010·The Veterinary Clinics of North America. Food Animal Practice·John A Ellis
Jun 6, 2007·Microbes and Infection·Takayuki KomatsuBin Gotoh
Oct 8, 2008·Immunological Reviews·Judith M FontanaPaul A Rota
Apr 19, 2008·The Journal of General Virology·Katrina SleemanPaul A Rota
Oct 20, 2006·Virology·Kay ChildsStephen Goodbourn
Nov 17, 2009·Microbes and Infection·Yoshinori KitagawaBin Gotoh
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Dec 1, 2009·Viruses·Raychel Chambers, Toru Takimoto
Jun 21, 2017·The Journal of General Virology·Maria Teresa Sánchez-AparicioAlina Baum

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