C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer

ACS Applied Materials & Interfaces
Hongjuan ZhaoZhenzhong Zhang

Abstract

Poor tumor accumulation, rapid clearance from blood circulation, and high risk of invasive and metastasis are the major barriers that encumber the conventional nanodrug-based tumor therapy. In this work, macrophage membrane (M)-camouflaged quercetin (QE)-loaded hollow bismuth selenide nanoparticles (abbreviated as M@BS-QE NPs) are fabricated for combination therapy of breast cancer. The resulting M@BS-QE NPs are comprehensively characterized, possessing prolonged circulation life, as well as accelerated and enhanced tumoritropic accumulation, compared with those of bare BS NPs because of the immune evading capacity, C-C chemokine ligand 2 (CCL2)-mediated recruitment properties, and active targeting ability. The subsequent QE release under near-infrared (NIR) laser irradiation can selectively sensitize cancer cells to photothermal therapy (PTT) by depleting heat shock protein 70 (HSP70, one malignancy-specific-overexpressed thermoresistance-related chaperone) to realize such a cascaded synergistic effect. At the same time, M@BS-QE NPs down-regulated p-Akt and matrix metalloproteinase-9 (MMP-9, which degrades the extracellular matrix to promote invasion and metastasis of tumors) signal axis to suppress breast cancer lung metastas...Continue Reading

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Citations

Jul 1, 2020·Journal of Drug Targeting·Xiaoyu ZhangYanhong Wang
Aug 29, 2020·Advanced Materials·Yuqiong XiaXiaoyuan Chen
Mar 3, 2019·International Journal of Molecular Sciences·Lisha Xiang, Daniele M Gilkes
Jul 28, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhimei He, Jun-Jie Zhu
Nov 22, 2020·Biology·Carla Jiménez-JiménezMaría Vallet-Regí
Mar 14, 2021·Colloids and Surfaces. B, Biointerfaces·Dandan TianYanqiu Ai
Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyan GuNianping Feng
Apr 16, 2021·International Journal of Nanomedicine·Tiantian LiangMeiling Zhou
Apr 20, 2021·Frontiers in Oncology·María Zenaida Saavedra-LeosMacrina Beatriz Silva-Cázares
Jun 9, 2021·Signal Transduction and Targeted Therapy·Li ChenZhiyao He
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab
Jun 15, 2021·Acta Biomaterialia·Da ZouChun-Xia Zhao
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chaojie ZhuQiwen Wang
Sep 2, 2021·Advanced Healthcare Materials·Dan WangLiangfang Zhang
Sep 17, 2021·Chemical Communications : Chem Comm·Yingshu GuoShusheng Zhang
Nov 6, 2021·Advanced Materials·Yuemin WangJianshu Li

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