C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits

Behavioural Brain Research
Pedro M Pimentel-CoelhoSerge Rivest

Abstract

Chemokines are a family of cytokines involved in the chemotaxis of leukocytes and other target cells by binding to specific G-protein-coupled receptors on their membranes. As such, the activation of C-C chemokine receptor type 2 (CCR2) is involved in the mobilization of "inflammatory" monocytes from bone marrow and in their recruitment to the brain under inflammatory/pathological conditions. In this study, we investigated whether CCR2 signaling could affect the progression of learning deficits and hippocampal damage in a model of neonatal hypoxic-ischemic (HI) brain injury. Postnatal day 3 wild-type (WT) and CCR2 knockout (KO) mice of both sexes were subjected to the Rice-Vannucci model of neonatal hypoxia-ischemia and were followed for up to 14 weeks. HI CCR2 KO male mice were the only animals to exhibit long-term spatial learning deficits in the T-water maze task, compared to their corresponding sham-operated controls. CCR2 KO mouse pups of both sexes had a lower number of circulating monocytes, although only HI CCR2 KO male mice exhibited reduced numbers of activated macrophages/microglia in the damaged hippocampus, compared to WT mice. However, no differences were observed in hippocampal atrophy between HI CCR2 KO and HI WT...Continue Reading

References

Feb 11, 1999·Journal of Neuroscience Research·R C VannucciS J Vannucci
Feb 25, 2000·Brain : a Journal of Neurology·D G GadianF Vargha-Khadem
Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Oliver B DimitrijevicAnuska V Andjelkovic
Apr 4, 2008·Annals of Neurology·Deanne K ThompsonTerrie E Inder
Jun 18, 2009·Brain : a Journal of Neurology·Alexander MildnerMarco Prinz
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hosung JungRichard J Miller
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gaëlle Naert, Serge Rivest
May 18, 2011·Biochemical and Biophysical Research Communications·Kana TsukudaMasatsugu Horiuchi
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander MildnerMarco Prinz
Jun 22, 2012·Annals of Neurology·Michael GliemSebastian Jander
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pedro M Pimentel-CoelhoSerge Rivest
May 2, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jean-Philippe MichaudSerge Rivest
Jul 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hannah X ChuChristopher G Sobey
Jul 22, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Cynthia Ortinau, Jeffrey Neil
Aug 26, 2014·Frontiers in Cellular Neuroscience·Knut Biber, Erik Boddeke
Aug 26, 2014·Frontiers in Cellular Neuroscience·Cristina Limatola, Richard M Ransohoff

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Citations

Jun 4, 2015·Glia·Estefania Acaz-FonsecaM Angeles Arevalo
Jul 19, 2016·Neurobiology of Disease·Elena ZenaroGabriela Constantin
Sep 7, 2016·Brain, Behavior, and Immunity·Wyston C PierreGregory A Lodygensky
Jun 21, 2017·Neurochemistry International·Chen ChenNai-Hong Chen
Dec 31, 2019·The European Journal of Neuroscience·Bérénice Le Dieu-LugonCarine Cleren
Aug 26, 2016·Reviews in the Neurosciences·Lan HuangDezhi Mu
Nov 22, 2016·Journal of Neuroscience Research·Carlos Alexandre NettoSimone Nardin Weis
May 16, 2021·Acta Physiologica·Aditya RayasamZinaida S Vexler

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