C-C motif ligand 11 reduction in CLL patients serum after vitamin D supplementation

Hematology
Marcin KubeczkoJerzy Wojnar

Abstract

Vitamin D (VD) deficiency results in a worse prognosis in patients with chronic lymphocytic leukemia (CLL) and may affect the production of cytokines. Nonetheless, there is the lack of studies dealing with VD supplementation and its impact on chemokines in CLL patients. The primary endpoint of our interventional study was to evaluate the effect of cholecalciferol supplementation on serum chemokines levels in CLL patients. Eighteen subjects with CLL were enrolled for the study. Six-month-long cholecalciferol supplementation was performed in CLL patients with serum 25-OH-D3 levels below 30 ng/ml. Cytokines levels were assessed at the beginning of the study and after 6 months. Baseline measurements of cytokines were compared to those in apparently healthy controls. Increased levels of CCL2, CCL3, CCL4, CXCL8, CXCL10, TNFα, bFGF, G-CSF, and VEGF were found in CLL patients in comparison with the healthy controls. In the course of the VD supplementation a decrease in serum levels of chemokines CCL11, CCL3, and cytokine PDGF-BB was observed. The decrease of CCL11 was found in CLL patients on VD supplementation solely, whereas the decrease of CCL3 and PDGF-BB was observed in CLL subjects on both chemotherapy and VD supplementation. The...Continue Reading

References

Jul 7, 1999·The Journal of Clinical Investigation·L TrentinG Semenzato
Aug 6, 2000·Circulation Research·D J MantellA E Canfield
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aihua LiRakesh K Singh
Feb 25, 2005·The New England Journal of Medicine·Nicholas ChiorazziManlio Ferrarini
Nov 3, 2005·Leukemia & Lymphoma·Evangelos TerposAmin Rahemtulla
Feb 2, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Diane L Kamen, Vin Tangpricha
May 28, 2010·The Journal of Investigative Dermatology·Tomomitsu MiyagakiShinichi Sato
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew T DrakeJames R Cerhan
Oct 27, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike Annette Bischoff-FerrariAndreas Egli
Nov 9, 2012·Journal of Leukocyte Biology·Reem KarmaliKent W Christopherson
Mar 1, 2013·International Journal of Cancer. Journal International Du Cancer·Agnieszka PiechnikKrzysztof Giannopoulos
Mar 12, 2013·Postȩpy higieny i medycyny doświadczalnej·Jakub BoguszPiotr Smolewski
Mar 21, 2015·International Archives of Allergy and Immunology·Paola Di FilippoFrancesco Chiarelli
Apr 1, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer L KellyJonathan W Friedberg
Apr 29, 2015·Nutrients·Margherita T CantornaLinlin Yang
Nov 19, 2015·International Journal of Molecular Sciences·Ewa MajJoanna Wietrzyk
Jan 5, 2016·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·Rosa Marlene Manjate CucoMohsin M Sidat

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

Bio
Statistica
Plex

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.