c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination

Cellular Signalling
Thomas OhrtRainer Niedenthal

Abstract

The p75 neurotrophin receptor (p75NTR) has dual functions in cell survival and cell death but its intracellular signalling pathways are not understood. Here we describe that in rat brain and in pervanadate-stimulated PCNA and HEK293 cells p75NTR is phosphorylated at a single tyrosine residue within the cytosolic C-terminus. Phosphorylated tyrosine 308 constitutes a binding site for the ubiquitin ligase c-Cbl. This interaction is a prerequisite for ubiquitination of p75NTR. Our data suggest a c-Cbl-dependent ubiquitination of p75NTR involved in the regulation of p75NTR signalling.

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Citations

Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rafal Butowt, Christopher S von Bartheld
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Tong ZhangNina F Schor
May 17, 2011·FEBS Letters·Yuga TakahashiNoriyuki Koibuchi
Feb 19, 2008·Molecular and Cellular Endocrinology·S SigalaP F Spano
Oct 18, 2015·Molecular and Cellular Neurosciences·Janina BerghoffJustin V McCarthy
Apr 17, 2012·Biochemical and Biophysical Research Communications·Thangiah GeethaJeganathan Ramesh Babu
Jun 3, 2006·Journal of Cellular Physiology·Gayathri Swaminathan, Alexander Y Tsygankov
Mar 2, 2005·The Journal of Biological Chemistry·Junjie Hu, Stevan R Hubbard
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Mar 25, 2017·International Journal of Molecular Sciences·Julia Sánchez-Sánchez, Juan Carlos Arévalo
Aug 3, 2021·Trends in Pharmacological Sciences·Subash C MalikChristian Schachtrup

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