C cell carcinoma of the thyroid. Follicular variant.

Acta Pathologica Japonica
N LertprasertsukeM Kubota

Abstract

A case of C cell carcinoma of the thyroid with an unusual follicular growth pattern of the cancerous C cells is described. The primary tumor consisted of a mixture of medullary and follicular features while the metastatic foci in the lymph nodes and liver displayed only a medullary arrangement. Histochemical study disclosed numerous argyrophilic cells in both the follicular and medullary parts. These cells were immunohistochemically positive for calcitonin, calcitonin gene-related peptide (CGRP) and other peptides as well as carcinoembryonic antigen (CEA), but negative for thyroglobulin. Radioimmunoassay done on the tissue extract revealed a high content of calcitonin. Electron microscopy showed small intracytoplasmic secretory granules and, in the follicular lining cells, formation of microvilli. A minor component consisting of glandular structures has been reported in medullary carcinoma of the thyroid, suggesting a potentiality for glandular differentiation of the C cells. In equivocal cases, immunohistochemical examination for calcitonin and thyroglobulin is essential for accurate diagnosis of thyroid carcinoma.

References

Sep 1, 1977·Acta Pathologica Japonica·K KakudoS Katayama
Oct 1, 1978·American Journal of Clinical Pathology·R A DeLellisH J Wolfe
Nov 1, 1979·Cancer·G Bussolati, G Monga
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KakudoK Watanabe
Feb 1, 1986·American Journal of Clinical Pathology·S M AldabaghJ B Taxy
Aug 9, 1973·Virchows Archiv. A: Pathology. Pathologische Anatomie·G BussolatiC Bordi
Sep 1, 1973·Acta Endocrinologica·J G LjunggrenB Hjern
Mar 1, 1966·Journal of Clinical Pathology·E D WilliamsI Doniach
Mar 1, 1966·Journal of Clinical Pathology·E D Williams
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·M PfaltzJ P Mühlethaler
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE
Dec 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane, G B Pierce

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Citations

Feb 1, 1995·Critical Reviews in Oncology/hematology·Y MizukamiH Nakamura
May 1, 1995·Pathology, Research and Practice·G BussolatiA Pagani
Sep 1, 1991·Veterinary Pathology·B LeblancC Jobit

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