PMID: 11914470Mar 27, 2002Paper

C-cell hyperplasia and medullary thyroid microcarcinoma

Endocrine Pathology
J Albores-Saavedra, J E Krueger

Abstract

Since the discovery of the thyroid C-cell, considerable progress has been made regarding its origin, function, and pathology. In this article an attempt is made to summarize and update our knowledge about physiologic or reactive C-cell hyperplasia, neoplastic C-cell hyperplasia (medullary carcinoma in situ), and medullary microcarcinoma. Seldom recognized preoperatively, physiologic C-cell hyperplasia is associated with inflammatory, metabolic, and neoplastic thyroid disorders as well as with hypercalcemia. However, the pathogenesis is still unclear. Although physiologic C-cell hyperplasia may progress to medullary carcinoma, the full malignant potential is unknown. Problems related to the definition of physiologic C-cell hyperplasia are discussed. Immunohistochemistry and quantitative analysis are required for the diagnosis. By contrast, C-cell hyperplasia associated with MEN II syndromes or familial medullary carcinoma can be diagnosed preoperatively in asymptomatic children or adolescents by the detection of germline mutations of the RET protooncogene. Morphologic and genetic abnormalities support the idea that C-cells in the familial form of C-cell hyperplasia are neoplastic and can be recognized with conventional stains. T...Continue Reading

Citations

Mar 17, 2004·Annals of Diagnostic Pathology·Jorge Albores-SaavedraMario Armando Luna
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Serge GuyétantJean-Paul Saint-André
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