C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization.

Current Biology : CB
Leigh R WexlerDouglas S Portman

Abstract

Dynamic integration of internal and external cues is essential for flexible, adaptive behavior. In C. elegans, biological sex and feeding state regulate expression of the food-associated chemoreceptor odr-10, contributing to plasticity in food detection and the decision between feeding and exploration. In adult hermaphrodites, odr-10 expression is high, but in well-fed adult males, odr-10 expression is low, promoting exploratory mate-searching behavior. Food-deprivation transiently activates male odr-10 expression, heightening food sensitivity and reducing food leaving. Here, we identify a neuroendocrine feedback loop that sex-specifically regulates odr-10 in response to food deprivation. In well-fed males, insulin-like (insulin/IGF-1 signaling [IIS]) and transforming growth factor β (TGF-β) signaling repress odr-10 expression. Upon food deprivation, odr-10 is directly activated by DAF-16/FoxO, the canonical C. elegans IIS effector. The TGF-β ligand DAF-7 likely acts upstream of IIS and links feeding to odr-10 only in males, due in part to the male-specific expression of daf-7 in ASJ. Surprisingly, these responses to food deprivation are not triggered by internal metabolic cues but rather by the loss of sensory signals associat...Continue Reading

References

Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E L PeckolC I Bargmann
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan LiptonScott W Emmons
Sep 24, 2004·BMC Developmental Biology·Tao LiuGarth I Patterson
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Todd R GruningerL Rene Garcia
Aug 15, 2006·PLoS Biology·Andy J ChangCornelia I Bargmann
Dec 16, 2006·The EMBO Journal·Alexander M van der LindenPiali Sengupta
Feb 3, 2007·Science·Sergiy LibertScott D Pletcher
Sep 29, 2007·Current Biology : CB·Wendy M ShawColeen T Murphy
Oct 30, 2007·Current Biology : CB·Kyunghwa Lee, Douglas S Portman
Oct 30, 2007·Current Biology : CB·Jamie Q WhiteErik M Jorgensen
Jul 8, 2008·PLoS Genetics·Todd R GruningerL Rene Garcia
Dec 9, 2008·Current Biology : CB·Arantza BarriosScott W Emmons
Apr 14, 2009·Nature Methods·Daniel G GibsonHamilton O Smith
Oct 24, 2009·PloS One·Juliette Ben ArousDidier Chatenay
May 3, 2011·PLoS Genetics·Sri Devi NarasimhanHeidi A Tissenbaum
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Aug 3, 2013·WormBook : the Online Review of C. Elegans Biology·Tina L Gumienny, Cathy Savage-Dunn
Jan 8, 2014·WormBook : the Online Review of C. Elegans Biology·Coleen T Murphy, Patrick J Hu
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William R MowreyDouglas S Portman
Jun 28, 2014·Seminars in Cell & Developmental Biology·Arantza Barrios
Feb 24, 2015·Cell·Yiming ChenZachary A Knight
Jul 15, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paola A CorreaL René García
May 5, 2016·Nature·Meital Oren-SuissaOliver Hobert
May 6, 2016·PLoS Biology·Ashiq HussainIlona C Grunwald Kadow
Jun 13, 2016·Trends in Endocrinology and Metabolism : TEM·George A Lemieux, Kaveh Ashrafi
Nov 22, 2016·Journal of Neuroscience Research·Douglas S Portman
Jul 7, 2017·Cell Metabolism·Celine E RieraAndrew Dillin

❮ Previous
Next ❯

Citations

Oct 8, 2020·Genetics·Steven W FlavellYoung-Jai You
Jul 25, 2020·Current Biology : CB·Hannah N LawsonDouglas S Portman
Sep 23, 2020·Current Biology : CB·Ronald E Ellis
May 7, 2021·Genetics·Steven W FlavellYoung-Jai You
Oct 7, 2021·Annual Review of Cell and Developmental Biology·Stephen F Goodwin, Oliver Hobert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.