C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.

PloS One
Sebastian J HonnenOlaf Bossinger

Abstract

The planar cell polarity (PCP) pathway is highly conserved from Drosophila to humans and a PCP-like pathway has recently been described in the nematode Caenorhabditis elegans. The developmental function of this pathway is to coordinate the orientation of cells or structures within the plane of an epithelium or to organize cell-cell intercalation required for correct morphogenesis. Here, we describe a novel role of VANG-1, the only C. elegans ortholog of the conserved PCP component Strabismus/Van Gogh. We show that two alleles of vang-1 and depletion of the protein by RNAi cause an increase of mean life span up to 40%. Consistent with the longevity phenotype vang-1 animals also show enhanced resistance to thermal- and oxidative stress and decreased lipofuscin accumulation. In addition, vang-1 mutants show defects like reduced brood size, decreased ovulation rate and prolonged reproductive span, which are also related to gerontogenes. The germline, but not the intestine or neurons, seems to be the primary site of vang-1 function. Life span extension in vang-1 mutants depends on the insulin/IGF-1-like receptor DAF-2 and DAF-16/FoxO transcription factor. RNAi against the phase II detoxification transcription factor SKN-1/Nrf2 also ...Continue Reading

References

May 1, 1974·Genetics·S Brenner
Dec 5, 1974·Journal of Molecular Biology·H F EpsteinS Brenner
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J LithgowT E Johnson
Dec 2, 1993·Nature·C KenyonR Tabtiang
Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
Dec 10, 1999·Developmental Biology·B LeungJ R Priess
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Feb 28, 2002·The EMBO Journal·Rachel S DarkenPaul A Wilson
Jul 19, 2003·Genes & Development·Jae Hyung An, T Keith Blackwell
Jul 29, 2003·Aging Cell·Bart P BraeckmanJacques R Vanfleteren
Sep 6, 2003·Free Radical Biology & Medicine·Matthew S GillGordon J Lithgow
Jul 1, 1956·Journal of Gerontology·D HARMAN
Mar 6, 2004·Science·W James Nelson, Roel Nusse
Jun 19, 2004·Free Radical Biology & Medicine·Edouard de CastroThomas E Johnson

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Citations

Dec 7, 2013·Genes & Nutrition·Helena SoaresFernando Antunes
Jan 19, 2016·Nature Cell Biology·Thijs KoormanMike Boxem
Sep 12, 2015·Annual Review of Genetics·Rosalind Hale, David Strutt
Jun 6, 2013·International Journal of Molecular Sciences·Christian BüchterWim Wätjen
Apr 20, 2018·Oxidative Medicine and Cellular Longevity·Fanhui MengYan Fu
Sep 26, 2019·Frontiers in Physiology·Marcos Francisco Perez, Ben Lehner
Dec 18, 2021·Science Advances·Aishwarya SubramanianW Brent Derry

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