C-F Bond Activation Mediated by Phosphorus Compounds

Chemistry : a European Journal
Julia M Bayne, Douglas W Stephan

Abstract

The activation and functionalization of C-F bonds has garnered significant attention in the scientific community as a strategy to mitigate toxicity and environmental concerns, as well as provide new pathways to agro- and pharmaceutical chemicals and materials. Although several transition-metal-based systems have been developed for this transformation, the use of main-group compounds remains less explored. In recent years, several strategies for C-F bond activation have focused on the use of phosphorus-based reagents. In this Minireview, an overview of strategies is provided that exploits PV and PIII -based Lewis acids as well as PIII Lewis bases in frustrated Lewis pair (FLP) protocols for hydrodefluorination, C-C couplings and C-F derivatizations.

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Citations

Jul 11, 2019·Chemical Communications : Chem Comm·Alexander E WakedDouglas W Stephan
Oct 15, 2019·Angewandte Chemie·Jiliang ZhouDouglas W Stephan
Sep 22, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Benedikt J GuddorfFelicitas Lips
Sep 29, 2020·Chemical Communications : Chem Comm·Jiliang ZhouDouglas W Stephan
Apr 17, 2021·Chemical Reviews·Hendrik F T KlareMartin Oestreich
Jul 1, 2021·Angewandte Chemie·Chuan ZhuChao Feng
Dec 8, 2020·Journal of the American Chemical Society·Junjian WangFrançois Mathey
Oct 20, 2020·Journal of the American Chemical Society·Michael M Wade WolfeNathaniel K Szymczak
Sep 16, 2021·Journal of the American Chemical Society·Daniel RothLutz Greb
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei Zhou
Jan 8, 2022·Dalton Transactions : an International Journal of Inorganic Chemistry·Aymeric DajnakEddy Maerten

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