PMID: 8610100Apr 2, 1996Paper

C factor, a cell-surface-associated intercellular signaling protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus

Proceedings of the National Academy of Sciences of the United States of America
L Søgaard-Andersen, D Kaiser

Abstract

C factor, an intercellular signaling protein, is required for aggregation and sporulation of the social bacterium, Myxococcus xanthus. We report that C factor, which normally is associated with the cell surface, provides input to the Frz signal transduction cascade. Elements of this cascade have sequence homology to bacterial chemotaxis systems and are known to control the frequency of gliding reversal. Exposure of developing cells of a C-factor-less mutant (csgA) to purified C factor increases the ratio of methylated to nonmethylated FrzCD protein, the Frz homolog of the methyl-accepting chemotaxis proteins. Methylation depends on the cognate methyltransferase FrzF, and its extent increases with the concentration of C factor. C-factor-induced methylation also depends on the product of a gene, called class II, which is necessary in vivo for all known responses to C factor. A model for aggregation is proposed in which C factor stimulates the Frz cascade and thereby decreases cell reversals in a way that preferentially leads cells into an aggregate.

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Citations

Jun 23, 2006·Applied Microbiology and Biotechnology·Toshiyuki Ueki, Sumiko Inouye
Apr 2, 2005·Current Opinion in Microbiology·Dale Kaiser, Rosa Yu
Nov 11, 2003·Journal of Microbiological Methods·Lars Jelsbak, Lotte Søgaard-Andersen
Jul 3, 1999·Trends in Genetics : TIG·D Kaiser
Oct 13, 2001·Trends in Microbiology·P J Bonner, L J Shimkets
Dec 21, 2000·Current Opinion in Microbiology·L Jelsbak, L Søgaard-Andersen
Mar 6, 1999·Current Opinion in Microbiology·D Kaiser
Dec 23, 1999·Current Opinion in Microbiology·M J Ward, D R Zusman
Mar 26, 2004·Nature Reviews. Microbiology·Dale Kaiser
Sep 6, 2000·Molecular Microbiology·E W Crawford, L J Shimkets
Nov 3, 2010·Molecular Biology and Evolution·Stuart HuntleyLotte Søgaard-Andersen
May 12, 2009·Journal of Bacteriology·Martin ClausenBerenike Maier
May 13, 2008·Journal of Bacteriology·Lee Kroos
Nov 14, 2006·Journal of Bacteriology·Oleksii SliusarenkoGeorge Oster
May 24, 2001·Journal of Bacteriology·J S Pollack, M Singer
Nov 8, 2001·Journal of Bacteriology·H Sun, W Shi
Sep 2, 2003·Journal of Bacteriology·Anders A Rasmussen, Lotte Søgaard-Andersen
Jan 19, 1999·Annual Review of Microbiology·J A Shapiro
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Fontes, D Kaiser
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·B JulienA Garza
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lars Jelsbak, Lotte Søgaard-Andersen
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Poorna ViswanathanLee Kroos
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Jelsbak, L Søgaard-Andersen
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Oleg A IgoshinGeorge Oster
Jul 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Toshiyuki Ueki, Sumiko Inouye
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M BurkartR M Harshey
Feb 6, 2007·Trends in Microbiology·Gitte Ebersbach, Christine Jacobs-Wagner
Nov 24, 2004·Current Opinion in Microbiology·Lotte Søgaard-Andersen
Aug 10, 2015·Journal of Molecular Biology·Pengbo CaoDaniel Wall
Jun 7, 2005·Trends in Microbiology·Angela Stevens, Lotte Søgaard-Andersen
Oct 19, 2004·Annual Review of Microbiology·Dale Kaiser
Sep 7, 2001·Annual Review of Microbiology·M J McBride
May 1, 2015·PLoS Computational Biology·Albertas JanuleviciusCristian Picioreanu

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