C-fiber activation exacerbates sleep-disordered breathing in rats

Sleep & Breathing = Schlaf & Atmung
David W CarleyMiodrag Radulovacki

Abstract

We reported previously that activation of vagal feedback by protoveratrines or serotonin exacerbates sleep apnea in rats, but each of these agents activates multiple afferent fiber types. To elucidate the specific impact of C-fiber activity on sleep apnea, the present study utilized capsaicin (CAP), which stimulates C-fibers via the CAP receptor. Nine adult Sprague-Dawley rats were instrumented for chronic polysomnography and recorded for 6 hours on four occasions. Prior to each recording, the animals received an intraperitoneal injection of either saline (control), or CAP 0.1, 1.0, or 10.0 mg/kg. Respiration was monitored by single-chamber plethysmography and apneas were scored as breaths longer than 2.5 seconds not preceded by a sigh. CAP increased apneas during non-rapid eye movement (NREM) sleep (p < 0.05 vs control) and reduced respiratory minute ventilation by about 15% in all behavioral states (waking, NREM, and REM sleep). We conclude that selective pharmacological activation of C-fibers produces a diathesis of sleep-disordered breathing specific to NREM sleep in rats.

References

Jan 1, 1985·Journal of Neural Transmission·J HednerJ Jonason
Apr 1, 1982·The Journal of Pharmacy and Pharmacology·A SariaF Lembeck
May 1, 1995·Pharmacology, Biochemistry, and Behavior·D MontiM Radulovacki
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·D W CarleyM Radulovacki
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·D W Carley, M Radulovacki

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Citations

Sep 1, 2012·Journal of Applied Physiology·Kun-Ze LeeJi-Chuu Hwang
Aug 13, 2008·Respiratory Physiology & Neurobiology·David W Carley, Miodrag Radulovacki
Jan 5, 2011·Respiratory Physiology & Neurobiology·Irina TopchiyDavid W Carley

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