C-Fos immunohistochemical localization of neurons in the mesencephalic locomotor region in the rat brain

Neuroscience
S M Brudzynski, D Wang

Abstract

The projection from the limbic system via the subpallidal region to the mesencephalic locomotor region is implicated in limbic-motor integration. The goal of this study was to visualize neurons of the mesencephalic locomotor region which are active during locomotor activity induced by the disinhibition of the subpallidal region. The subpallidal region was disinhibited by picrotoxin, which antagonizes the effects of GABA. The unilateral injection of picrotoxin into the subpallidal region caused a significant increase in locomotor activity. Active tegmental neurons were subsequently visualized by immunocytochemical staining of c-Fos protein. There were significantly more immunostained neurons in the picrotoxin-injected animals than in the saline-treated rats. Heavily stained neuronal nuclei, prevailing on the brain side ipsilateral to the injection of picrotoxin, were localized within a narrow strip of tissue which stretched from the ventrolateral periaqueductal gray (including the dorsal raphe), the cuneiform nucleus, through the region of the dorsal tegmental bundle to the pedunculopontine nucleus. There were 3.5 times more immunostained neurons in the cuneiform/pedunculopontine region and 2.5 times more stained neurons in the ...Continue Reading

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Citations

Apr 27, 2000·Neuroscience and Biobehavioral Reviews·P R LamingK Ng
Feb 3, 1999·Annals of the New York Academy of Sciences·L M Jordan
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Phil Hyu LeeKyoon Huh
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Dec 5, 2019·Frontiers in Systems Neuroscience·Ioan OprisBrian R Noga

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