c-Fos induction in the rat nucleus of the solitary tract by intraoral quinine infusion depends on prior contingent pairing of quinine and lithium chloride

Physiology & Behavior
T A HouptG P Smith

Abstract

Intraoral infusions of sucrose or saccharin induce c-Fos-like immunoreactivity (c-FLI) in the intermediate nucleus of the solitary tract (iNTS) of rats after acquisition of a conditioned taste aversion (CTA). The induction of c-FLI in the iNTS may be a consequence of the shift in behavioral response from ingestive to aversive behaviors that characterize acquisition and expression of a CTA. To test this hypothesis, rats were intraorally infused with 0.3 mM quinine sulfate, an aversive taste, 1. prior to conditioning, 2. after 3 noncontingent (unpaired) infusions of quinine and toxic lithium chloride (LiCl) injections, 3. after conditioning with 3 contingent pairings of quinine and LiCl, and 4. after extinction with repeated unpaired infusions of quinine. Intraoral infusions of quinine induced c-FLI in the iNTS only after acquisition of a CTA against quinine; quinine failed to induce c-FLI in the iNTS of unconditioned, noncontingently treated, or extinguished rats. The pattern of c-FLI in the iNTS induced by expression of a CTA against quinine was quantitatively and anatomically similar to that elicited by sucrose in rats expressing a CTA against sucrose. We conclude that aversive responses per se are not sufficient to induce c-F...Continue Reading

References

Oct 1, 1980·Journal of Comparative and Physiological Psychology·G H NowlisC Pfaffmann
May 1, 1993·Pharmacology, Biochemistry, and Behavior·A Tyrka, G P Smith

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Citations

Nov 5, 1999·Physiology & Behavior·T R Scott, C R Plata-Salamán
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·D LancellottiA L Riley
May 19, 2000·Neuroscience and Biobehavioral Reviews·A C Spector
Oct 31, 2000·Nutrition·T A Houpt
Jul 6, 2004·Brain Research·G Andrew MickleyDawn R Remmers-Roeber
Jun 18, 2005·Brain Research·G Andrew MickleyJaclyn M Biada

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