Abstract
Out-of-hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post-OHCA remains difficult in patients receiving targeted temperature management. Retrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32-34°C) for 24 hours at a tertiary-care center from 2008 to 2012 (development cohort, n=122). The primary outcome was favorable neurologic outcome at hospital discharge, defined as cerebral performance category 1 to 2 (poor 3-5). Patient demographics, pre-OHCA diagnoses, and initial laboratory studies post-resuscitation were compared between favorable and poor neurologic outcomes with multivariable logistic regression used to develop a simple scoring system (C-GRApH). The C-GRApH score ranges 0 to 5 using equally weighted variables: (C): coronary artery disease, known pre-OHCA; (G): glucose ≥200 mg/dL; (R): rhythm of arrest not ventricular tachycardia/fibrillation; (A): age >45; (pH): arterial pH ≤7.0. A validation cohort (n=344) included subsequent patients from the initial site (n=72) and an external quaternary-care health system (n=272) from 2012 to 2014. The c-statistic for predict...Continue Reading
References
Nov 14, 1991·The New England Journal of Medicine·W A GrayA S Most
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Jun 20, 2002·Critical Care Medicine·Mary Beth HamelJoel Tsevat
Sep 15, 2004·Intensive Care Medicine·Stephen LaverJerry Nolan
Jul 26, 2006·Neurology·E F M WijdicksUNKNOWN Quality Standards Subcommittee of the American Academy of Neurology
Nov 4, 2006·European Heart Journal·Christophe AdrieMehran Monchi
Oct 29, 2008·Resuscitation·Tuomas OksanenVille Pettilä
Apr 8, 2010·Annals of Neurology·Andrea O RossettiPeter W Kaplan
Aug 4, 2010·Neurocritical Care·Edgar A SamaniegoChristine A C Wijman
Nov 10, 2010·Annals of Neurology·Jennifer E FugateAlejandro A Rabinstein
Apr 13, 2011·Resuscitation·Koichi HayakawaTakeshi Shimazu
Aug 13, 2011·Resuscitation·Young-Min KimClifton W Callaway
Aug 26, 2011·Resuscitation·Justin B LundbyeJeffrey Kluger
Jan 28, 2012·Resuscitation·Kazuhiro OkadaShinichi Ishimatsu
Mar 21, 2013·Critical Care : the Official Journal of the Critical Care Forum·Claudio SandroniMassimo Antonelli
Jul 13, 2013·Critical Care : the Official Journal of the Critical Care Forum·Yoshikazu GotoYumiko Goto
Aug 7, 2013·Resuscitation·Anne V GrossestreuerDavid F Gaieski
Nov 19, 2013·The New England Journal of Medicine·Niklas NielsenUNKNOWN TTM Trial Investigators
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Oct 6, 2015·Circulation·Michael W DonninoUNKNOWN ILCOR ALS Task Force
Oct 17, 2015·Circulation·Robert W NeumarMary Fran Hazinski
Citations
Jun 22, 2018·Acta Anaesthesiologica Scandinavica·J DüringH Friberg
Aug 17, 2017·Therapeutic Hypothermia and Temperature Management·Justin LundbyeLindsay Boyd
Apr 25, 2020·PloS One·Hyun Soo KimChun Song Youn
Aug 14, 2020·Journal of the American Heart Association·Richard T CarrickDavid M Kent
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Joshua R LuptonMohamud R Daya
May 15, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amir LotfiSean van Diepen
Jan 4, 2021·Resuscitation·Dae Hee BaeYong Il Min
Apr 11, 2021·Resuscitation·Nikolaos I NikolaouUNKNOWN International Liaison Committee on Resuscitation Advanced Life Support Task Force (ILCOR)
May 1, 2021·Journal of Clinical Medicine·Ho Gul SongChangshin Kang
Jul 6, 2021·Resuscitation Plus·Talal AlnabelsiVedant A Gupta
Aug 16, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Takumi TsuchidaMineji Hayakawa
Oct 5, 2021·Frontiers in Medicine·Matthias MuellerFlorian Ettl
Dec 18, 2021·Scientific Reports·Armin WeissWolfgang Lederer