C-GRApH : A Validated Scoring System for Early Stratification of Neurologic Outcome After Out-of-Hospital Cardiac Arrest Treated With Targeted Temperature Management

Journal of the American Heart Association
Erich L KiehlLawrence W Gimple

Abstract

Out-of-hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post-OHCA remains difficult in patients receiving targeted temperature management. Retrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32-34°C) for 24 hours at a tertiary-care center from 2008 to 2012 (development cohort, n=122). The primary outcome was favorable neurologic outcome at hospital discharge, defined as cerebral performance category 1 to 2 (poor 3-5). Patient demographics, pre-OHCA diagnoses, and initial laboratory studies post-resuscitation were compared between favorable and poor neurologic outcomes with multivariable logistic regression used to develop a simple scoring system (C-GRApH). The C-GRApH score ranges 0 to 5 using equally weighted variables: (C): coronary artery disease, known pre-OHCA; (G): glucose ≥200 mg/dL; (R): rhythm of arrest not ventricular tachycardia/fibrillation; (A): age >45; (pH): arterial pH ≤7.0. A validation cohort (n=344) included subsequent patients from the initial site (n=72) and an external quaternary-care health system (n=272) from 2012 to 2014. The c-statistic for predict...Continue Reading

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Citations

Jun 22, 2018·Acta Anaesthesiologica Scandinavica·J DüringH Friberg
Aug 17, 2017·Therapeutic Hypothermia and Temperature Management·Justin LundbyeLindsay Boyd
Aug 14, 2020·Journal of the American Heart Association·Richard T CarrickDavid M Kent
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Joshua R LuptonMohamud R Daya
May 15, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amir LotfiSean van Diepen
Apr 11, 2021·Resuscitation·Nikolaos I NikolaouUNKNOWN International Liaison Committee on Resuscitation Advanced Life Support Task Force (ILCOR)
Aug 16, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Takumi TsuchidaMineji Hayakawa

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Software Mentioned

SPSS
R
GRApH

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