C-It: a knowledge database for tissue-enriched genes

Bioinformatics
Pascal GellertShizuka Uchida

Abstract

Due to the development of high-throughput technologies such as microarrays, it has become possible to determine genome-wide expression changes in a single experiment. Although much attention has been paid to identify differentially expressed genes, the functions of tens of thousands of genes in different species still remain unknown. C-It is a knowledge database that has its focus on 'uncharacterized genes'. C-It contains expression profiles of various tissues from human, mouse, rat, chicken and zebrafish. By applying our previously introduced algorithm DGSA (Database-Dependent Gene Selection and Analysis), it is possible to screen for uncharacterized, tissue-enriched genes in the species mentioned above. C-It is designed to include further expression studies, which might provide more comprehensive coverage of gene expression patterns and tissue-enriched splicing isoforms. We propose that C-It will be an excellent starting point to study uncharacterized genes. C-It is freely available online without registration at http://C-It.mpi-bn.mpg.dehttp://C-It.mpi-bn.mpg.de.

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Citations

Apr 21, 2012·BMC Medicine·Ioannis PrassasEleftherios P Diamandis
Jun 28, 2011·Stem Cell Reviews and Reports·Shizuka UchidaThomas Braun
Jul 15, 2015·Bioinformatics·Tyler WeirickShizuka Uchida
Jul 26, 2015·Fertility and Sterility·Joana Vieira SilvaMargarida Fardilha
Jan 17, 2015·BMC Bioinformatics·Joana Vieira SilvaMargarida Fardilha
Apr 18, 2019·Journal of Biological Research·Syed Aun MuhammadJake Y Chen

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