c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model

Molecular Cancer Research : MCR
Crispin R DassPeter F M Choong

Abstract

The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone.

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Citations

Feb 14, 2009·Cancer Metastasis Reviews·Hang T TaDave E Dunstan
Nov 15, 2011·DNA and Cell Biology·Soo-Hyun Kim, Crispin R Dass
Feb 26, 2009·Expert Opinion on Drug Delivery·Mei Lin TanCrispin R Dass
Jan 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei Lin TanCrispin R Dass
Jul 2, 2009·ANZ Journal of Surgery·J C M ClarkP F M Choong
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Mei Lin TanCrispin R Dass
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Iván Cárcamo-OriveCésar Trigueros
Dec 21, 2010·Bone·David E RothemMichael Soudry
Nov 25, 2020·Journal of Experimental & Clinical Cancer Research : CR·Ju-Fang LiuChun-Han Hou

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