c-Jun N-terminal kinase-mediated anti-inflammatory effects of Garcinia subelliptica in macrophages

Molecular Medicine Reports
Young-Chang Cho, Sayeon Cho

Abstract

Garcinia plants have been traditionally used to treat inflammatory diseases, such as skin infections and pain, in many regions including South‑East Asia. Garcinia subelliptica, a plant of the Garcinia species widely distributed from Japan to Thailand, has been reported to contain components similar to other Garcinia plants that exhibit anti‑inflammatory effects. The present study aimed to explore the anti‑inflammatory effects of ethanol extracts of Garcinia subelliptica (EGS) in macrophages, as there are no previous systemic studies that have investigated the effects of Garcinia subelliptica on inflammation. Non‑cytotoxic concentrations of EGS (≤200 µg/ml) were observed to reduce nitric oxide production by modulating iNOS expression in lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. The expression of cyclooxygenase‑2, the enzyme responsible for the production of prostaglandin E2, was notably reduced by EGS. EGS treatment inhibited the production of pro‑inflammatory cytokines, including IL‑6 and IL‑1β, however, not TNF‑α. Reduced production of inflammatory mediators by EGS was followed by reduced phosphorylation of c‑Jun N‑terminal kinase (JNK) however, not of other mitogen‑activated protein kinases and nuclear factor...Continue Reading

References

Sep 23, 1994·Cell·C Nathan, Q W Xie
Feb 1, 1995·Chemical & Pharmaceutical Bulletin·H MinamiK Nakagawa
Jan 1, 1995·Advances in Pharmacology·C Szabó, C Thiemermann
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Jul 15, 1998·Arthritis and Rheumatism·R M ClancyS B Abramson
Aug 26, 1998·Clinical and Experimental Immunology·K D KrönckeV Kolb-Bachofen
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E CarioD K Podolsky
Feb 5, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B Calixto
Nov 17, 2001·Phytochemistry·Hiroyuki MinamiYoshiyasu Fukuyama
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 13, 2003·Chemistry : a European Journal·Jing-Ru WengJih-Pyang Wang
Dec 1, 2004·Journal of Natural Products·Jing-Ru WengChun-Nan Lin
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Nagatoshi Fujiwara, Kazuo Kobayashi
Aug 22, 2006·Immunobiology·Kate SchroderDavid A Hume
Nov 1, 2006·Nature Clinical Practice. Rheumatology·Norihiro Nishimoto, Tadamitsu Kishimoto
Mar 16, 2007·Journal of Ethnopharmacology·Ampai PanthongVichai Reutrakul
Mar 24, 2007·Bioinformatics·Triinu Koressaar, Maido Remm
Dec 6, 2008·Journal of Ethnopharmacology·Supinya TewtrakulWilawan Mahabusarakam
Jan 23, 2013·Basic & Clinical Pharmacology & Toxicology·Ebenezer O FarombiEwomazino E Egbeme
May 8, 2013·Chemical & Pharmaceutical Bulletin·Tetsuro ItoMunekazu Iinuma
Dec 24, 2013·BMC Complementary and Alternative Medicine·Omolola R AyepolaOluwafemi O Oguntibeju
Jul 2, 2014·Molecular Nutrition & Food Research·Mei-Ling TsaiMin-Hsiung Pan

❮ Previous
Next ❯

Citations

Mar 8, 2018·Journal of Neural Engineering·Steven T WalstonJames D Weiland
Oct 31, 2019·Journal of Neural Engineering·Wei TongMichael Ibbotson
Jul 17, 2020·The American Journal of Chinese Medicine·Young-Chang ChoSayeon Cho
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·YoungSook YunHideshi Inoue

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here