c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways

FEBS Letters
S MruthyunjayaShastry Padma

Abstract

In this study, we demonstrated that laminin-1 (LM-1) induces neurite outgrowth and enhances the expression of neurofilament-L and MAP2 in human bone marrow mesenchymal stem cells (MSCs). The c-Jun transcription factor was strongly activated by LM-1 during neurite induction. Suppression of c-Jun inhibited the expression of the c-Jun target genes α6 integrin and neurofilament-L, resulting in the loss of neurite outgrowth. Additionally, we found that the LM-1-α6 integrin interaction stimulated phosphorylation of FAK, leading to the activation of JNK and Akt. Pharmacological inhibition of these pathways blocked c-Jun activation and neurite outgrowth. Collectively, our findings suggest that c-Jun/AP-1 activity mediated by JNK, PI3K/Akt and ERK pathways is required for LM-1-induced neurite outgrowth in human bone marrow MSCs.

References

Jan 13, 1998·Biochemical and Biophysical Research Communications·K NishidaS Kitazawa
Oct 19, 2000·Experimental Cell Research·C A WestonB S Weeks
Nov 10, 2000·Brain Research. Molecular Brain Research·M DragunowM During
Aug 3, 2001·Blood Cells, Molecules & Diseases·I B Black, D Woodbury
Jun 24, 2004·Journal of Neuroscience Research·Paul LuMark H Tuszynski
Jun 25, 2004·Molecular Biology of the Cell·Motoaki MiyashitaTakashi Matozaki
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Jan 18, 2005·Journal of Cell Science·Sabrina Paganoni, Adriana Ferreira
Feb 16, 2006·Journal of Neuroscience Research·Lisa A FlanaganEdwin S Monuki
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Oct 11, 2008·Tissue Engineering. Part C, Methods·Rebekah A NealEdward A Botchwey
May 1, 2009·International Journal of Cancer. Journal International Du Cancer·Mari KielostoErkki Hölttä
Oct 14, 2009·Expert Opinion on Biological Therapy·Ofer SadanDaniel Offen
Mar 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Colin M NorthNorbert E Kaminski
May 25, 2010·Developmental Cell·Stephanie L Gupton, Frank B Gertler
Jul 10, 2010·OncoTargets and Therapy·Victoria BolósEnrique Grande
Aug 5, 2010·Science Progress·Pedro Cesar ChagastellesMelissa Camassola

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Citations

Jan 8, 2014·Journal of Signal Transduction·Panagiotis ApostolouIoannis Papasotiriou
May 29, 2014·Journal of Biomedical Materials Research. Part a·S MruthyunjayaPadma Shastry
Apr 8, 2020·Translational Stroke Research·Amanda L TroutGregory J Bix
Jan 7, 2021·Journal of Photochemistry and Photobiology. B, Biology·David Diaz VeraAbigail N Koppes
Jan 14, 2021·International Journal of Molecular Sciences·Hana LeeSeok-Jun Kim
Nov 27, 2018·ACS Applied Materials & Interfaces·Wei JiSamuel I Stupp

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