C-kit and its ligand stem cell factor: potential contribution to prostate cancer bone metastasis.

Neoplasia : an International Journal for Oncology Research
Christoph WiesnerR Daniel Bonfil

Abstract

The tyrosine kinase receptor c-kit and its ligand stem cell factor (SCF) have not been explored in prostate cancer (PC) bone metastasis. Herein, we found that three human PC cell lines and bone marrow stromal cells express a membrane-bound SCF isoform and release a soluble SCF. Bone marrow stromal cells revealed strong expression of c-kit, whereas PC cells showed very low levels of the receptor or did not express it all. Using an experimental model of PC bone metastasis, we found that intraosseous bone tumors formed by otherwise c-kit-negative PC3 cells strongly expressed c-kit, as demonstrated using immunohistochemical and Western blot analyses. Subcutaneous PC3 tumors were, however, c-kit-negative. Both bone and subcutaneous PC3 tumors were positive for SCF. Immunohistochemical analysis of human specimens revealed that the expression frequency of c-kit in epithelial cells was of 5% in benign prostatic hyperplasia, 14% in primary PC, and 40% in PC bone metastases, suggesting an overall trend of increased c-kit expression in clinical PC progression. Stem cell factor expression frequency was more than 80% in all the cases. Our data suggest that the bone microenvironment up-regulates c-kit expression on PC cells, favoring their i...Continue Reading

Citations

Oct 15, 2010·Molecular Carcinogenesis·Leigh-Ann MacFarlane, Paul R Murphy
Jan 19, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuanyuan MaZhenhe Suo
Oct 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haili HuangMingyi Li
Jul 7, 2015·Prostate Cancer·Dima Y JadaanJohn P McCabe
Jul 12, 2017·Stem Cells International·Koran S Harris, Bethany A Kerr
Aug 24, 2018·Biomedicines·Shaker A MousaPaul J Davis
Feb 26, 2011·Hormones & Cancer·Hsing-Jien Kung
Jul 23, 2016·International Journal of Molecular Sciences·Kaile ZhangXiaolan Fang
Nov 3, 2017·Calcified Tissue International·Sun H ParkYusuke Shiozawa
Dec 7, 2017·BMC Veterinary Research·Carlos Eduardo Fonseca-AlvesRenée Laufer-Amorim
Jan 29, 2010·Cancer·Toni IbrahimDino Amadori
Jan 18, 2015·Oncotarget·Bethany A KerrTatiana V Byzova
Dec 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li WangFeng Luo
Feb 20, 2018·Molecular Cancer·Zhenfang Du, Christine M Lovly
Jun 1, 2018·Medicine·Reyisha TaximaimaitiHaimiti Abudulimu
Mar 9, 2018·Biomedicines·Brittni M FosterBethany A Kerr
Nov 2, 2014·Molecular Reproduction and Development·Henrique J CardosoSílvia Socorro
Sep 18, 2009·The Prostate·Helmut Bonkhoff, Richard Berges
Sep 2, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anupam MishraAmita Pandey
May 7, 2014·International Journal of Cancer. Journal International Du Cancer·Leandro E MainettiR Daniel Bonfil
Jul 30, 2019·The Tohoku Journal of Experimental Medicine·Farah Hanan Fathihah JaffarSiti Fatimah Ibrahim
Jun 26, 2020·Physiological Reviews·Paul J DavisHung-Yun Lin
Feb 7, 2012·Cancer Research·Paola Pittoni, Mario Paolo Colombo
Jan 16, 2021·Scientific Reports·Koran S HarrisBethany A Kerr
May 15, 2021·Expert Opinion on Pharmacotherapy·Vincent ChauJeanny B Aragon-Ching
Aug 14, 2021·Zygote : the Biology of Gametes and Early Embryos·Romualdo SciorioSandro C Esteves
Aug 28, 2021·Experimental and Molecular Pathology·Brittni M FosterBethany A Kerr

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