c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract

Cell and Tissue Research
S TorihashiK M Sanders

Abstract

In vivo injection of a neutralizing, monoclonal antibody (ACK2) to the receptor tyrosine kinase (c-kit) disrupts the normal motility patterns of the mouse small intestine. Immunohistochemical studies showed that cells expressing c-kit-like immunoreactivity (c-kit-LI) decreased in numbers in response to ACK2, but the identity of these cells is unknown. We investigated the identity and development of the cells that express c-kit-LI in the mouse small intestine and colon. Cells in the region of the myenteric plexus and deep muscular plexus of the small intestine and in the subserosa, in the myenteric plexus region, within the circular and longitudinal muscle layers, and along the submucosal surface of the circular muscle in the colon were labeled with ACK2. The distribution of cells that express c-kit-LI was the same as that of interstitial cells (ICs). In whole-mount preparations cells with c-kit-LI were interconnected, forming a network similar to the network formed by cells that stained with methylene blue, which has been used as a marker for ICs in the mouse gastrointestinal tract. Immunocytochemistry verified that ICs were labeled with ACK2. Multiple injections of animals with ACK2 between days 0 and 8 post partum (pp) caused...Continue Reading

Associated Clinical Trials

Sep 21, 2020·Nipaporn Pichetshote

References

Mar 1, 1992·The American Journal of Physiology·N G PublicoverK M Sanders
Jan 1, 1992·Annual Review of Physiology·K M Sanders
Feb 1, 1992·Journal of the Autonomic Nervous System·J Christensen
Apr 1, 1989·The American Journal of Physiology·N KirshnerH P Erickson
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P LangtonK M Sanders
Nov 1, 1989·Journal of the Autonomic Nervous System·C A Du, J L Conklin
Mar 1, 1986·The Journal of Physiology·Y HaraJ H Szurszewski
Feb 1, 1987·The American Journal of Physiology·T K SmithK M Sanders
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N G PublicoverK M Sanders

❮ Previous
Next ❯

Citations

Aug 10, 2005·International Journal of Colorectal Disease·Ahmed ShafikIsmail Ahmed
Aug 19, 2008·Journal of Gastroenterology·Yasushi AdachiYasuo Kato
Sep 8, 2006·Digestive Diseases and Sciences·Jieyun YinJ D Z Chen
Dec 4, 2003·Current Opinion in Pharmacology·Sang Don KohBurton Horowitz
Jun 5, 2003·Journal of Pediatric Surgery·Anna Piaseczna PiotrowskaPrem Puri
Dec 23, 1998·Journal of the Autonomic Nervous System·R HaggerD Kumar
Feb 6, 1999·Journal of the Autonomic Nervous System·S TorihashiY Watanabe
Jun 20, 2002·Cancer Genetics and Cytogenetics·Avery A Sandberg, Julia A Bridge
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·L K Ashman
Dec 9, 2000·Autonomic Neuroscience : Basic & Clinical·L D BurtonD Greenwood
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·N HudsonG Pearson
Mar 21, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H B MikkelsenL Thuneberg
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ferdinand RossiPeter Besmer
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Emily CozziDavid R Beier
Jan 27, 2011·Journal of Gastroenterology and Hepatology·Yimin LiHiroshi Kimura
Apr 1, 1999·Annual Review of Physiology·W A Kunze, J B Furness
Apr 1, 1999·Annual Review of Physiology·B HorowitzK M Sanders
Apr 1, 1999·Annual Review of Physiology·T B BoltonD V Gordienko
Feb 8, 2006·Annual Review of Physiology·Kenton M SandersSean M Ward
Jan 18, 2002·Stem Cells·Takatsugu YamadaYukio Tsunoda
Jan 16, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Othman A Al-Shboul
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J BurnsS M Ward
Apr 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pedro J Gomez-PinillaGianrico Farrugia
Jul 25, 2009·American Journal of Physiology. Cell Physiology·Nan Ge JinKenton M Sanders
Dec 10, 2009·World Journal of Gastroenterology : WJG·Byung Joo KimSeon Jeong Kim
Apr 30, 2010·Biology of Reproduction·Rose Ellen DixonSean M Ward
Aug 3, 2010·World Journal of Gastroenterology : WJG·Sam-Ryong JeeMark Pimentel
Jul 1, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ahmed ShafikIsmail A Shafik
Jun 1, 2000·Leukemia & Lymphoma·S MooreT P Hughes
Apr 10, 2010·Scandinavian Journal of Gastroenterology·Weidong TongBaohua Liu
Sep 23, 2006·Scandinavian Journal of Gastroenterology·Xiaomin SunHesheng Luo
Feb 3, 2004·The Journal of Physiology·G W HennigT K Smith
Jun 3, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S G MárquezC G Barbeito
Apr 1, 1997·The British Journal of Surgery·R HaggerD Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.