PMID: 8964895Apr 1, 1996Paper

C-kit ligand (Stem Cell Factor) affects neuronal activity, stimulates pituitary-adrenal axis and prolactin secretion in rats

Journal of Neuroimmunology
K J KovácsE S Vizi

Abstract

Stem Cell Factor (SCF) is a potent growth factor affecting proliferation, differentiation and migration as well as secretory functions of various cells of different origin and function. The effect of SCF on neuronal activity and on neuroendocrine regulation has been studied by injecting SCF i.v. into conscious male rats. Administration of SCF elevated adrenocorticotropin (ACTH), corticosterone and prolactin (PRL) plasma levels in a dose-dependent manner. Adrenocorticotropin and corticosterone secretions were maximal after injecting 10 micrograms SCF, while prolactin secretion only reached a maximum at a dose of 20 micrograms. Hormone secretions were maximal at 15 min (ACTH and PRL) or at 30 min (CORT) and declined to the baseline between 90 and 180 min. The functional anatomical approach, using immediate-early gene product c-Fos as a marker of activated neurones, revealed that systemic administration of SCF activated neurosecretory neurones of the hypothalamus in a time-dependent manner. Somatosensory afferent pathways and extrahypothalamic areas--which are involved in the regulation of hypothalamic neurosecretory cells--including various parts of the lamina terminalis, bed nucleus of stria terminalis, central amygdala, locus c...Continue Reading

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Citations

Aug 7, 2002·The Journal of Clinical Investigation·Kunlin JinDavid A Greenberg
Apr 25, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Francesco BenedettiHemmo A Drexhage
Jul 27, 2000·Molecular Reproduction and Development·K ReynaudM A Driancourt

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