PMID: 8605274Jan 1, 1996Paper

C-kit receptor (CD117) expression in acute leukemia

Annals of Hematology
L R ValverdeD Catovsky

Abstract

The murine monoclonal antibody YB5.B8 (CD117) identifies a transmembrane tyrosine kinase receptor encoded by the human c-kit proto-oncogene. In this study we investigated the expression of c-kit on different types of acute leukemia to determine the degree of specificity and sensitivity of this marker for the myeloid and lymphoid lineages. C-kit was positive in over half of the 115 cases of acute leukemia studied. Overall, two thirds of AML cases expressed c-kit, whereas only one of 23 ALL patients was c-kit positive. C-kit was also positive in 16 of 19 cases of myeloid blast crisis of myeloproliferative disorders and negative in four with a lymphoid phenotype. There was no correlation between c-kit expression and the degree of myeloid differentiation by FAB subtypes or other markers. We conclude that c-kit is a specific marker for the myeloid lineage, which is expressed early during hematopoietic differentiation and can aid the diagnosis of AML in difficult cases. More patients need to be tested to establish whether the expression of c-kit may define AML subgroups of prognostic significance.

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Citations

May 6, 1999·Leukemia Research·J F NomdedéuE Rubiol
Aug 6, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Markku Miettinen, Jerzy Lasota
Jun 8, 2006·International Journal of Hematology·Shinya FujisawaMasahide Kobayashi
Feb 16, 2013·Annals of Hematology·Sandra HeeschClaudia D Baldus
Aug 26, 1998·Leukemia & Lymphoma·L EscribanoJ F San Miguel
Feb 28, 2002·American Journal of Clinical Pathology·Christine P HansCharles W Ross
Apr 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Abbas AhmadiAmir Amini
Aug 30, 2008·Seminars in Immunology·Sidinh LucSten Eirik W Jacobsen
Feb 9, 2010·Oral Oncology·Sachin C SarodeAnuprita Patil
Mar 26, 2005·Immunology Letters·Marie C Béné
Feb 25, 2009·Leukemia Research·Prashant SharmaSeema Tyagi
Dec 22, 2005·American Journal of Hematology·Kikkeri N Naresh, Irvin A Lampert
Jul 8, 1998·European Journal of Haematology·F TajimaH Kawasaki

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