c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors

Oncotarget
Katia Corano ScheriAngela Catizone

Abstract

Type II testicular germ cell tumors (TGCTs) represent the most frequent malignancy in Caucasian males (20-40 years). Even if diagnosed with disseminated disease, >80% of patients are cured; however, a small percentage of cases progress and result in death. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche that leads to the block of gonocyte differentiation. The subsequent development of the invasive seminomas and non-seminomas is due to a combination of genetic, epigenetic and microenvironment-based alterations (genvironment). Hepatocyte growth factor (HGF) is present in the testicular microenvironment, together with its receptor c-MET, from early embryonic development to an adult stage. In addition, c-MET is a well-known proto-oncogene involved in the onset and progression of various human cancers. Herein, we have investigated the expression and availability of HGF and c-MET in TCam-2, NCCIT and NT2D1 cells, which are type II (T)GCT representative cell lines, and the effect of c-MET activation/repression on the regulation of cancerous biological processes. We found that NT2D1 cells increase their proliferation, polarized migration, and invasion in response to HGF administration. NCCIT...Continue Reading

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Citations

Jan 17, 2019·International Journal of Molecular Sciences·Erica LeonettiAngela Catizone
Nov 21, 2020·International Journal of Molecular Sciences·Luisa GesualdiAngela Catizone
Apr 16, 2020·International Journal of Molecular Sciences·Giulia BagnatoBarbara Peruzzi

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
Confocal microscopy
PCR
FCS
FACS
immunoprecipitation
protein assay

Software Mentioned

Genikon
FCS Express
ImageJ
Image Lab

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