c-myc amplification in a preleukemia patient with trisomy 4 and double minutes: review of the unique coexistence of these two chromosome abnormalities in acute myelogenous leukemia

Cancer Genetics and Cytogenetics
K S Reddy, V Sulcova

Abstract

Cytogenetic analysis of the bone marrow from a woman with preleukemia showed an aberrant clone with trisomy 4, double minutes, and a translocation t(8;9)(q21;q34). Fluorescence in situ hybridization (FISH) demonstrated that the double minutes were c-myc amplifications. A review of six cases in the literature and the present case with trisomy 4 and double minutes showed a preponderance of females and that the patients were mostly elderly. The acute myelogenous leukemia (AML) in these patients was either FAB subtype M2 or M4. In two out of seven cases, the double minutes were c-myc amplicons. The patients responded to treatment and there was karyotypic normalization during remission. There was no strong evidence of exposure to genotoxic agents.

References

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Citations

Dec 24, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Erich Gebhart
Jul 21, 1998·Leukemia Research·C Mecucci
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A De Benedetti, A L Harris
Jun 13, 2002·Reviews in Clinical and Experimental Hematology·Cristina MecucciRoberta La Starza
Feb 6, 2013·International Journal of Cancer. Journal International Du Cancer·Jing ZhuSongbin Fu
Dec 8, 2004·Annales de génétique·Aline ReceveurFlorence Nguyen-Khac
Apr 20, 2004·Oncogene·Arrigo De Benedetti, Jeremy R Graff
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik

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