c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Ali OzdekTaner Yilmaz

Abstract

To evaluate the expression and prognostic significance of c-myc and bcl-2 oncogenes in squamous cell carcinoma (SCC) of the supraglottic larynx. Study design A retrospective cohort study of 61 patients who underwent surgery for SCC of the supraglottic larynx. Gender, age, TNM status, operative procedure, recurrences, and disease-free survival periods were recorded. Hematoxylin and eosin-stained sections were reexamined for grade, invasion of tumor margins, lymphovascular invasion, lymphocyte infiltration, and perineural invasion. Immunohistochemical detection of c-myc and bcl-2 oncogenes was performed using monoclonal antibodies. No correlation was observed between either c-myc or bcl-2 and the clinical and histopathologic parameters. Survival analysis revealed no correlation of either c-myc (P = 0.88) or bcl-2 (P = 0.85) with the disease-free survival. c-myc expression was found to be significantly higher in bcl-2-positive patients (P = 0.001). Neither c-myc nor bcl-2 had shown to be prognostic factor for laryngeal carcinoma in this present study. Correlation between c-myc and bcl-2 supports the experimental observations of cooperative action between these two genes in tumorigenesis.

References

Oct 8, 1992·Nature·R P BissonnetteD R Green
May 1, 1992·American Journal of Otolaryngology·B H HaugheyP M Mock
Jan 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H SakaiN Hashimoto
Mar 1, 1994·Archives of Otolaryngology--head & Neck Surgery·M GapanyJ L Gluckman
Aug 22, 1996·International Journal of Cancer. Journal International Du Cancer·M SarbiaH E Gabbert
Mar 1, 1997·The Annals of Otology, Rhinology, and Laryngology·E M Friedman
Apr 1, 1997·Archives of Otolaryngology--head & Neck Surgery·R P TakesJ H van Krieken
Jun 1, 1997·The Annals of Otology, Rhinology, and Laryngology·M FriedmanJ S Coon
May 20, 1998·The Laryngoscope·L C WhislerJ S Coon
Dec 29, 1998·Archives of Otolaryngology--head & Neck Surgery·S SaraçS Kaya
Apr 20, 1999·Archives of Otolaryngology--head & Neck Surgery·M A HotzM M Borner
Aug 24, 1999·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J KlatkaD Skomra

❮ Previous
Next ❯

Citations

Oct 16, 2015·The Journal of Cell Biology·Zhipeng ZouXiaochun Bai
Jun 4, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Federico Maria GioacchiniMassimo Re
Nov 4, 2006·The Journal of Biological Chemistry·Jagruti H Patel, Steven B McMahon
Jan 18, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·N PallaviSanthosh Kumar S Hiremath
Oct 15, 2005·The Journal of Biological Chemistry·Elizabeth S YehAnthony R Means
Jan 16, 2015·The International Journal of Biological Markers·Federico Maria GioacchiniMassimo Re
Jul 3, 2021·International Journal of Molecular Sciences·Marinela BostanCarmen Cristina Diaconu
Aug 11, 2020·Journal of Oral Biology and Craniofacial Research·Ruby DwivediRahul Pandey
Jul 10, 2021·Annals of Diagnostic Pathology·Matteo CavaliereClaudia Cassandro

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
dissections

Software Mentioned

SPSS

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.