c-Myc and EBV-LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells.

British Journal of Cancer
C S TudorMaike Buettner

Abstract

Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) up-regulates the human leukocyte antigen (HLA) class I antigen presentation machinery (APM). This appears counterintuitive with immune evasion in EBV-associated tumours like nasopharyngeal carcinoma (NPC). Latent membrane protein 1-transfected epithelial cell lines were used as a model system to study the impact of LMP1 and c-Myc on HLA class I components. The expression of components of the HLA class I APM, c-Myc and Ki-67 was analysed in LMP1+ and LMP1- NPC by immunohistochemistry. In epithelial cells, LMP1 up-regulated HLA class I APM. This effect could be counteracted by c-Myc, which itself was up-regulated by LMP1 apparently through IL6 induction and Jak3/STAT3 activation. Studies of NPC biopsies revealed down-regulation of HLA class I APM expression. No difference was observed between LMP1+ and LMP1- NPC. However, expression of Ki-67 and c-Myc were up-regulated in LMP1+ tumours. These findings raise the possibility that c-Myc activation in NPC might antagonise the effect of LMP1 on HLA class I expression thus contributing to immune escape of tumour cells.

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Citations

Jun 4, 2015·Emerging Microbes & Infections·Yong ShenJing Qian
Jul 28, 2016·Frontiers in Microbiology·Xiaofan Li, Sumita Bhaduri-McIntosh
May 26, 2017·International Journal of Cancer. Journal International Du Cancer·Angela Kwok-Fung LoKwok-Wai Lo
Jul 21, 2017·JCI Insight·Zipei FengBernard A Fox
Jan 23, 2021·Oncogene·Nicholas J CampionGhassan Alusi

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Methods Mentioned

BETA
biopsies
electrophoresis
Transfection

Software Mentioned

FACSDiva
SPSS17

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