C-MYC and Its Main Ubiquitin Ligase, FBXW7, Influence Cell Proliferation and Prognosis in Adult T-cell Leukemia/Lymphoma

The American Journal of Surgical Pathology
Yasuhito MihashiMorishige Takeshita

Abstract

Smoldering-type and chronic-type adult T-cell leukemia/lymphomas (ATLL) patients have relatively indolent clinical courses, but often progress into aggressive lymphoma-type and acute-type disease. We examined the roles of transcription factor C-MYC and its ubiquitin ligase FBXW7 in tumor tissues from 137 patients with ATLL. Immunohistochemical tests showed ≥50% of lymphoma cells in 78.7% (48/61) of lymphoma-type, and 64.9% (24/37) of acute-type samples expressed C-MYC, significantly higher than was seen in smoldering-type (3.6%) and chronic-type (9.1%) samples (P<0.01). Real-time polymerase chain reaction showed C-MYC mRNA expression in lymphoma-type and acute-type samples were significantly higher than in smoldering-type (P<0.01). C-MYC expression was highly correlated with its mRNA levels (ρ=0.65, P<0.0001), chromosomal amplification and duplication (ρ=0.3, P=0.045) and MIB1 labeling index (ρ=0.69, P<0.0001). Expression of FBXW7 protein and mRNA in lymphoma-type samples were significantly lower than those of smoldering-type (P<0.01 for each), and both were inversely correlated with C-MYC (protein: ρ=-0.4, P=0.0002; mRNA: ρ=-0.31, P=0.015). Seven patients with smoldering-type or chronic-type ATLL converted to acute-type, in 4 ...Continue Reading

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Citations

Feb 23, 2019·Cancers·Bethsebie Lalduhsaki SailoAjaikumar Bahulayan Kunnumakkara
Mar 26, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Katsumi KobataMorishige Takeshita
Jul 1, 2020·Cancer Medicine·Katsumi KobataMorishige Takeshita
May 30, 2020·The Journal of International Medical Research·Er Chen, Renzhi Pei
Nov 21, 2020·British Journal of Haematology·Mahsa KhanlariJie Xu
Jul 6, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ninghan ZhangMingshan Niu

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