c-myc, c-fos, and c-jun regulation in the regenerating livers of normal and H-2K/c-myc transgenic mice.

Molecular and Cellular Biology
D MorelloN Fausto

Abstract

We investigated the mechanisms of regulation of c-myc, c-fos, and c-jun at the early stages of liver regeneration in mice. We show that the transient increase in steady-state levels of c-myc mRNA at the start of liver regeneration is most probably regulated by posttranscriptional mechanisms. Although there was a marked increase in c-myc transcriptional initiation shortly after partial hepatectomy, a block in elongation prevented the completion of most transcripts. To gain further information on the mechanism of regulation of c-myc expression during liver regeneration, we used transgenic mice harboring the human c-myc gene driven by the H-2K promoter. In these animals, the murine c-myc responded to the growth stimulus generated by partial hepatectomy, whereas the expression of the transgene was constitutive and did not change in the regenerating liver. However, the mRNA from both genes increased markedly after cycloheximide injection, suggesting that the regulation of c-myc mRNA abundance in the regenerating liver differs from that occurring after protein synthesis inhibition. Furthermore, we show that in normal mice c-fos and c-jun mRNA levels and transcriptional rates increase within 30 min after partial hepatectomy. c-fos tra...Continue Reading

References

Apr 29, 1987·Biochemical and Biophysical Research Communications·S HorikawaK Tsukada
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Wright, J M Bishop
Nov 1, 1989·Molecular and Cellular Biology·A Richman, A Hayday
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E Mead, N Fausto
Dec 15, 1988·Nature·T Kouzarides, E Ziff
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Ryder, D Nathans
Dec 1, 1987·Molecular and Cellular Biology·T R Jones, M D Cole
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Jan 1, 1987·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K B Marcu
Aug 1, 1984·Molecular and Cellular Biology·M GoyetteN Fausto
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C DaniP Jeanteur
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Jul 2, 1981·Nature·F BrégégèreB Dobberstein

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Citations

Jul 27, 2001·Journal of Clinical Gastroenterology·D S Seaman
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert H CostaXinhe Wang
Dec 1, 2005·Journal of Cellular Biochemistry·Kirk BergstromChow H Lee
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kirsten C SadlerChinweike Ukomadu
Sep 1, 1991·Gut·C D Gove, R D Hughes
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YamadaN Fausto
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·B L BennettD W Anderson
Mar 27, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yukihiro YokoyamaYuji Nimura
Jul 11, 2012·Stem Cells and Development·Haruhiko ShugoAtsushi Hirao
Feb 28, 2014·Cellular and Molecular Life Sciences : CMLS·Ivan Ferrer-VicensElena R García-Trevijano
Feb 1, 1993·Journal of Cellular Physiology·P SchmiedebergM J Czaja
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L G KoniarisJ M Farber
Jan 2, 2003·The Journal of Biological Chemistry·Torsten WuestefeldChristian Trautwein
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert H CostaI-Ching Wang
Jan 27, 2009·Journal of Cellular Physiology·Isabel M OlazabalJosefa P García-Ruiz
Apr 16, 2015·Electrophoresis·Jinjun HeDacheng He
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Zaret
Jun 28, 2015·Biochemical Genetics·Cuifang ChangCunshuan Xu
Feb 16, 2018·Journal of Virology·Savvina MoustafaPenelope Mavromara
Jun 5, 2012·Expert Opinion on Drug Delivery·Yitzhak RosenNoel M Elman
Jul 1, 1992·The American Journal of Physiology·R Tran-PatersonD M Miller
Oct 6, 1998·The Journal of Surgical Research·Y PanisJ C Emond
Mar 8, 2000·Mechanisms of Development·K S Zaret
Mar 23, 2000·Journal of Hepatology·N Fausto
Dec 10, 1991·Biochimica Et Biophysica Acta·C V Dang

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