c-Myc, genome instability, and tumorigenesis: the devil is in the details

Current Topics in Microbiology and Immunology
M Wade, G M Wahl

Abstract

The c-myc oncogene acts as a pluripotent modulator of transcription during normal cell growth and proliferation. Deregulated c-myc activity in cancer can lead to excessive activation of its downstream pathways, and may also stimulate changes in gene expression and cellular signaling that are not observed under non-pathological conditions. Under certain conditions, aberrant c-myc activity is associated with the appearance of DNA damage-associated markers and karyotypic abnormalities. In this chapter, we discuss mechanisms by which c-myc may be directly or indirectly associated with the induction of genomic instability. The degree to which c-myc-induced genomic instability influences the initiation or progression of cancer is likely to depend on other factors, which are discussed herein.

Citations

Nov 10, 2010·Journal of Applied Toxicology : JAT·Edmundo L R PereiraRommel R Burbano
Nov 10, 2010·The Journal of Experimental Medicine·Letetia JonesScott C Kogan
Jul 4, 2012·Antioxidants & Redox Signaling·Qi MaEnrique A Mesri
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Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Youjun LiEdward V Prochownik
Apr 25, 2020·Cancers·Antonino Carbone
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