c-Myc, Genomic Instability and Disease

Genome Dynamics
F Kuttler, S Mai

Abstract

The proto-oncogene c-myc has been the subject of intensive research since its discovery. It is already known that this oncogene targets multiple pathways for the initiation and promotion of tumor formation, and that deregulation of this protein is observed in numerous cancers. However, despite the plethora of information gathered, the exact role and mechanism of action of the protein still remains enigmatic. This review focuses on the role of the c-Myc protein in the induction of genomic instability and its link with the development of cancer. We briefly describe c-Myc protein, its binding partners and downstream targets as well as its role in inducing genomic instability and the c-myc-related diseases in humans and mice with regard to genomic instability. This review emphasizes the notions that c-Myc is a multifunctional protein which also affects the stability of the whole genome and triggers the initiation of a complex network of genomic instability and therefore acts beyond the characteristics of classical transcription factors that only regulate a limited number of downstream targets. We propose that c-Myc is a structural modifier of the genome that affects the nuclear organization and an important molecule in tumor cell p...Continue Reading

Citations

Feb 17, 2010·The Journal of Biological Chemistry·Youjun LiEdward V Prochownik
Mar 3, 2010·Journal of Neurosurgery. Pediatrics·Claudia FariaLúcia Roque
Jun 26, 2014·Stem Cells and Development·Joel S SchneiderAndreas S Ivessa
Feb 24, 2015·Frontiers in Cell and Developmental Biology·Vimal K SinghRamesh Chandra
Dec 3, 2016·Cell Biology and Toxicology·Dharmendra KumarWilfried A Kues
Oct 3, 2009·Annals of the New York Academy of Sciences·Dirk DuinsbergenHarald Mikkers
Dec 14, 2011·Journal of Molecular Cell Biology·Libing SongJun Li
May 17, 2018·Stem Cells International·Navneet Kumar DubeyWin-Ping Deng

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