C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection

Open Biology
Mohammad HaqueJianxun Song

Abstract

The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals.

References

Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SureshR Ahmed
Mar 25, 2004·The Journal of Biological Chemistry·Masamichi InamiToshinori Nakayama
Feb 22, 2005·Nature Cell Biology·Azadeh ArabiAnthony P H Wright
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajan M ThomasAndrew D Wells
Nov 28, 2006·Nature Immunology·Jianxun SongMichael Croft
Dec 16, 2006·Journal of Molecular Endocrinology·Niamh CosgraveLeonie S Young
Apr 13, 2007·European Journal of Immunology·Aihua SongMichael Croft
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie B BorowskiPeter D Katsikis
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinichiro FuseEdward J Usherwood
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianxun SongMichael Croft
Sep 3, 2008·Cellular & Molecular Immunology·Jianxun SongRizwanul Haque
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shahram Salek-ArdakaniMichael Croft
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Baohua ZhaoJianxun Song
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Zhi Hong FangZhong Chao Han
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Vassilis PapanikolaouAspasia Tsezou
Oct 25, 2011·Nature Cell Biology·Iris UribesalgoLuciano Di Croce
Sep 13, 2012·PLoS Pathogens·Tobias BoettlerMatthias G von Herrath
Oct 20, 2012·Nature Reviews. Immunology·Susan M Kaech, Weiguo Cui
Feb 12, 2013·Nature Immunology·J Adam BestUNKNOWN Immunological Genome Project Consortium
May 7, 2013·Nature Immunology·Michael MingueneauShannon Turley
May 29, 2013·The Journal of Experimental Medicine·Rodrigo Hess MicheliniStephen M Hedrick
Sep 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kui S VooYong J Liu
Nov 2, 2013·Cancer Research·Brendan D CurtiAndrew D Weinberg
Feb 11, 2014·The Journal of Clinical Investigation·Jeffrey C Nolz, John T Harty

❮ Previous
Next ❯

Citations

Apr 23, 2019·Immunology and Cell Biology·Alexander D McLellan, Seyed M Ali Hosseini Rad
Nov 4, 2020·Immunology and Cell Biology·Liqing WangJianxun Song
Feb 13, 2021·International Journal of Molecular Sciences·Theodoros EleftheriadisIoannis Stefanidis

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
ELISA
nuclear translocation
flow cytometry
histone acetylation
Profiler

Software Mentioned

GraphPad P rism

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Critical Reviews in Immunology
Priyanka A DuttaguptaPeter D Katsikis
The Journal of Immunology : Official Journal of the American Association of Immunologists
Nu Zhang, You-Wen He
The Journal of Immunology : Official Journal of the American Association of Immunologists
Tania H Watts
© 2022 Meta ULC. All rights reserved