PMID: 591131Dec 15, 1977

C. parvum immuntherapy of transplanted rat tumours

International Journal of Cancer. Journal International Du Cancer
M V Pimm, R W Baldwin

Abstract

C.parvum (Wellcome CN 6134) has been tested for tumour suppression against a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. Subcutaneous growth was not prevented by distant subcutaneous or intravenous injection of the preparation, although growth rates were sometimes depressed or accelerated. In contrast, C. parvum injected in admixture with tumour cells consistently suppressed their growth and with highly immunogenic tumours induced systemic tumour immunity, C. parvum injected intravenously retarded development of pulmonary tumour deposits, and intrapleural injection suppressed growth of pleural tumours and malignant effusions. Host immunosuppression failed to abrogate the tumour-suppressive effect of locally applied C. parvum, but host macrophage depletion with silica totally abolished the response. These studies indicate that in the rat, tumour suppression is most consistently achieved by regional application of C. parvum, and that this response is more dependent upon local macrophage stimulation than generation of systemic immune responses.

References

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Citations

Jan 1, 1979·Journal of Immunopharmacology·S M Mikulski, M A Chirigos
Sep 15, 1979·International Journal of Cancer. Journal International Du Cancer·N WillmottR W Baldwin
Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·M V PimmR W Baldwin
May 1, 1979·The British Journal of Surgery·M Woodruff

Related Concepts

Therapeutic Immunosuppression
Immunotherapy
Malignant Neoplasm of Lung
Neoplasm Transplantation
Neoplasms, Experimental
Pleural Effusion Disorder
Propionibacterium acnes

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