C-Peptide and atherogenesis: C-Peptide as a mediator of lesion development in patients with type 2 diabetes mellitus?

Experimental Diabetes Research
N Marx, Daniel Walcher

Abstract

Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show increased levels of C-peptide and over the last years various groups examined the effect of C-peptide in vascular cells as well as its potential role in lesion development. While some studies demonstrated beneficial effects of C-peptide, for example, by showing an inhibition of smooth muscle cell proliferation, others suggested proatherogenic mechanisms in patients with type 2 diabetes. Among them, C-peptide may facilitate the recruitment of inflammatory cells into early lesions and promote lesion progression by inducing smooth muscle cell proliferation. The following review will summarize the effects of C-peptide in vascular cells and discuss the potential role of C-peptide in atherogenesis in patients with type 2 diabetes.

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Citations

Sep 15, 2015·Advances in Pharmacological Sciences·Alis GuillénNorman Balcázar
Nov 20, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhaoxia LiuJiachun Chen
Feb 15, 2011·Experimental Diabetes Research·Sandra M BarbalhoVanessa Sellis da Silva
Feb 20, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Antonio Cabrera de LeónMaría del Cristo Rodríguez Pérez
Jan 23, 2020·International Journal of Molecular Sciences·Selma B SoutoEliana B Souto
Oct 22, 2013·Cardiovascular Research·Young-Cheol LimKwon-Soo Ha
Nov 8, 2018·BMC Endocrine Disorders·Romildo Luiz Monteiro AndradeBernardo Lessa Horta
Mar 19, 2015·Rheumatology International·Mathias BurgmaierVincent Brandenburg

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Methods Mentioned

BETA
transfection

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