C-peptide and insulin levels at 24-30 weeks' gestation: an increased risk of adverse pregnancy outcomes?

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Herbert ValensiseDomenico Arduini

Abstract

The hypothesis was that fasting C-peptide and insulin values, during an oral glucose tolerance test (OGTT), might allow an estimation of the increased risk for gestational hypertension (GH) and fetal macrosomia. Two-hundred and six consecutive patients were submitted to an OGTT. Thirty-five developed gestational hypertension and 29 delivered large-for-gestational-age (LGA) newborns. Plasma glucose levels (mg/dl) and insulin levels (microU/ml) were measured fasting and after 60, 120 and 180 min C-peptide fasting levels (ng/ml) were also measured. Twenty-five patients were excluded, 181 were enrolled. According to the OGTT, 143 patients were classified as normal, 26 were found affected by gestational diabetes (GD) mellitus, and 12 had impaired gestational glucose tolerance (IGGT). Hypertensive women exhibited higher 60 and 120 min insulin values than the normotensive group (128.3+/-69.9 microU/ml versus 86.2+/-58.3 microU/ml, P<0.05; 104.9+/-66.4 microU/ml versus 78.7+/-56.5 microU/ml, P<0.05).C-peptide cut-off at 2.9 ng/ml resulted predictive for patients delivering large-for-gestational-age newborns (OR=3.42, 95% CI=1.59-7.39). C-peptide and insulin may be used as indicators of risk for the development of complications in late ...Continue Reading

References

Dec 1, 1977·American Journal of Obstetrics and Gynecology·S G GabbeE J Quilligan
May 1, 1991·Statistics in Medicine·P Royston
Feb 1, 1990·Metabolism: Clinical and Experimental·T PollareC Berne
Aug 1, 1988·American Journal of Obstetrics and Gynecology·W A BaumanO Langer
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Apr 1, 1988·American Journal of Obstetrics and Gynecology·D A Davey, I MacGillivray
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·V ManicardiE Ferrannini
Mar 1, 1985·The Journal of Clinical Investigation·M ModanZ Fuchs
May 1, 1983·Metabolism: Clinical and Experimental·E BonoraU Butturini
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·P OlofssonD Ursing
Apr 19, 1995·JAMA : the Journal of the American Medical Association·R A Reeves
Jan 1, 1993·Diabetes Care·B HoegsbergD R Coustan
Mar 1, 1993·The Journal of Clinical Endocrinology and Metabolism·D C MullerR Andres
Nov 14, 1997·Obstetrics and Gynecology·I M BernsteinK C Copeland
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M A BrownJ M Moutquin
Aug 1, 1954·Acta Endocrinologica·J PEDERSEN
Nov 1, 1949·The American Journal of Medicine·P WHITE

❮ Previous
Next ❯

Citations

Jan 14, 2003·Ugeskrift for laeger·Kjeld Leisgård Rasmussen
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Kristine Y Lain, Patrick M Catalano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie
D BettelheimG Bemaschek
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
A GilillandM A Rich
The Journal of Emergency Medicine
Rajan U Popat, Craig P Adams
© 2022 Meta ULC. All rights reserved