C-peptide as a key risk factor for non-alcoholic fatty liver disease in the United States population

World Journal of Gastroenterology : WJG
Amporn AtsawarungruangkitGeorge Dickstein

Abstract

To determine whether fasting C-peptide is an independent predictor for non-alcoholic fatty liver disease (NAFLD) in United States population. Using the National Health and Nutrition Examination Survey (NHANES) 1988-1994, NAFLD participants aged 20 or greater without any other liver diseases were included in this study. Excessive alcohol intake is defined as > 2 drinks per day for males and > 1 drink per day for females. C-peptide and 27 other factors known to be associated with NAFLD (e.g., age, gender, body mass index, waist circumference, race/ethnicity, liver chemistries, and other diabetes tests) were tested in both univariate and multivariate level using logistic regression with a P-value 0.05. Of 18825 participants aged ≥ 20, 3235 participants (n = 3235) met inclusion criteria. There were 23 factors associated with NAFLD by univariate analysis. 9 factors, ranked by the highest change in pseudo R2 , were found to be significant predictors of NAFLD in multivariate model: waist circumference, fasting C-peptide, natural log of alanine aminotransferase (ALT), total protein, being Mexican American, natural log of glycated hemoglobin, triglyceride level, being non-Hispanic white, and ferritin level. Together with waist circumfer...Continue Reading

References

Apr 29, 1999·The Journal of the American Board of Family Practice·C M WaickusA Shakil
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Mar 1, 2003·Diabetes Care·Jaana Lindström, Jaakko Tuomilehto
Feb 27, 2004·The American Journal of Clinical Nutrition·Ian JanssenRobert Ross
Jun 23, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·H NyblomR Olsson
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Jan 11, 2007·Pediatric Diabetes·Andrew HattersleyUNKNOWN International Society for Pediatric and Adolescent Diabetes
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kris V KowdleyUNKNOWN NASH Clinical Research Network
Jul 17, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sven M A FrancqueLuc Van Gaal
Feb 23, 2013·World Journal of Gastroenterology : WJG·Takehiro OkabayashiKazuhiro Hanazaki
Jul 9, 2013·The Journal of Endocrinology·Mohamed Asrih, François R Jornayvaz
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
May 16, 2014·Journal of Crohn's & Colitis·Ingo MecklenburgUNKNOWN Swiss IBD Cohort Study Group
Aug 19, 2014·Lancet·Børge G Nordestgaard, Anette Varbo
Nov 8, 2014·Alimentary Pharmacology & Therapeutics·C E Ruhl, J E Everhart
May 23, 2015·Journal of the American Heart Association·Michelle D SchmiegelowMark A Hlatky
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Jun 26, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pathik ParikhPrabha Sawant
Jan 30, 2016·Metabolism: Clinical and Experimental·Elena BuzzettiEmmanuel A Tsochatzis
Feb 11, 2016·Metabolic Syndrome and Related Disorders·M Elba Gonzalez-MejiaRicardo Pérez-Fuentes
Feb 13, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kyriakos DimitriadisDimitris Tousoulis
Dec 21, 2016·The American Journal of Gastroenterology·Paul Y KwoJoseph K Lim
May 10, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Emma LeightonGregory C Jones
Apr 18, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Domenico TricòNicola Santoro

❮ Previous
Next ❯

Citations

Jul 28, 2019·Diabetes/metabolism Research and Reviews·Ningjian WangYingli Lu
Feb 19, 2020·Diabetes Technology & Therapeutics·Kavita GargSatish K Garg
Feb 16, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Mohammad Hassan SohouliVihan Moodi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.