PMID: 1001852Dec 1, 1976

C-peptide in children with juvenile diabetes. A preliminary report

Diabetologia
J Ludvigsson, L G Heding

Abstract

Serum C-peptide, insulin-binding IgG and total insulin (IRI) were determined in 96 juvenile diabetics aged 4-21 years, with onset of diabetes at the age of 1-16 years and with 2-17 years' duration of diabetes. Thirty-four patients (35.4%) had detectable levels of C-peptide (greater than or equal to 0.04 pmol/ml). Compared to non-diabetic adults, 19 had values below the normal range, 12 showed values within the normal range (0.18-0.63 pmol/ml) and 3 rated above normal. There was a negative correlation between the fasting C-peptide concentration and the degree of ketonuria at the onset of diabetes and a positive correlation between C-peptide levels and the incidence of post-initial remission periods. Patients without detectable C-peptide had significantly higher levels of insulin antibodies than those who had detectable levels of C-peptide. The possibility of a relationship between the intensity of the initial treatment of diabetes and the preservation of the B-cell function is discussed, as well as the possibility of insulin antibodies being a cause of B-cell exhaustion.

References

Apr 18, 2001·Diabetes/metabolism Research and Reviews·J LudvigssonL Stenhammar
Jan 1, 1977·Diabetologia·J LudvigssonL G Heding
Oct 1, 1979·Acta diabetologica latina·J Ludvigsson, Y Larsson
Apr 1, 1984·Acta diabetologica latina·M CignarelliR Giorgino
Oct 1, 1990·Journal of Ethnopharmacology·E R ShanmugasundaramB Kizar Ahmath
Mar 1, 1980·The Journal of Pediatrics·M MenchiniG Chiumello
Jun 1, 1979·Australian and New Zealand Journal of Medicine·F I Martin, L Simeanova
Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·L G Heding, J Ludvigsson
Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·J Ludvigsson, L G Heding
Mar 1, 1985·Archives of Disease in Childhood·S Rogers, M Silink
May 30, 2008·Experimental Diabetes Research·Dietrich Brandenburg
Nov 1, 1977·The Journal of Clinical Investigation·J BarbosaE J Yunis
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Oct 31, 2009·Diabetes/metabolism Research and Reviews·J Ludvigsson
Sep 14, 2011·Pediatric Diabetes·J LudvigssonU Samuelsson
Oct 20, 2012·Diabetes/metabolism Research and Reviews·U SamuelssonBetter Diabetes Diagnosis study group
Jan 1, 1991·Diabetes Research and Clinical Practice·J J CouperL C Harrison
Nov 1, 1988·Acta paediatrica Scandinavica·G DahlquistS Wall
Feb 1, 1982·Australian and New Zealand Journal of Medicine·C GlatthaarE A Espiner
Nov 1, 1982·Acta paediatrica Scandinavica·M KnipH K Akerblom
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·A TanaeI Hibi
Jul 1, 1977·Clinics in Endocrinology and Metabolism·M ChristyJ Nerup
Aug 1, 2014·Annals of Pediatric Endocrinology & Metabolism·Min Jung ChoDae-Yeol Lee
Dec 22, 2012·Diabetes·Werner Waldhäusl
May 18, 2016·ELife·Lena Eliasson, Anna Wendt

Citations

Jun 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·O K FaberC Binder
Jun 1, 1975·The Journal of Clinical Investigation·D L HorwitzA H Rubenstein
Jun 1, 1975·Diabetologia·L G Heding, S M Rasmussen
Nov 1, 1974·Pediatric Clinics of North America·R M Ehrlich
Nov 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G FinkL Recant
Feb 1, 1973·Metabolism: Clinical and Experimental·A Drash
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A H Christiansen
Jan 1, 1970·Annual Review of Medicine·D Porte, J D Bagdade
Oct 1, 1971·Diabetologia·M A BatallaR F Bradley
Dec 1, 1965·Diabetes·R B ElliottC C Roy
Jan 1, 1980·Acta Paediatrica Scandinavica. Supplement·L G Heding, J Ludvigsson

Related Concepts

Remission, Spontaneous
C-Peptide
Insulin B Chain
Teens
Ketosis
Polypeptides
Ketone Bodies
Diabetes, Autoimmune
Age Factors
Insulin Antibodies

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.