PMID: 1001852Dec 1, 1976

C-peptide in children with juvenile diabetes. A preliminary report

J Ludvigsson, L G Heding


Serum C-peptide, insulin-binding IgG and total insulin (IRI) were determined in 96 juvenile diabetics aged 4-21 years, with onset of diabetes at the age of 1-16 years and with 2-17 years' duration of diabetes. Thirty-four patients (35.4%) had detectable levels of C-peptide (greater than or equal to 0.04 pmol/ml). Compared to non-diabetic adults, 19 had values below the normal range, 12 showed values within the normal range (0.18-0.63 pmol/ml) and 3 rated above normal. There was a negative correlation between the fasting C-peptide concentration and the degree of ketonuria at the onset of diabetes and a positive correlation between C-peptide levels and the incidence of post-initial remission periods. Patients without detectable C-peptide had significantly higher levels of insulin antibodies than those who had detectable levels of C-peptide. The possibility of a relationship between the intensity of the initial treatment of diabetes and the preservation of the B-cell function is discussed, as well as the possibility of insulin antibodies being a cause of B-cell exhaustion.


Apr 18, 2001·Diabetes/metabolism Research and Reviews·J LudvigssonL Stenhammar
Jan 1, 1977·Diabetologia·J LudvigssonL G Heding
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Related Concepts

Remission, Spontaneous
Insulin B Chain
Ketone Bodies
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Age Factors
Insulin Antibodies

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