PMID: 15220188Jun 29, 2004Paper

C-peptide induces chemotaxis of human CD4-positive cells: involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase

Diabetes
Daniel WalcherNikolaus Marx

Abstract

Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes, a high-risk population for the development of a diffuse and extensive pattern of arteriosclerosis. The present study examined the effect of C-peptide on CD4(+) lymphocyte migration, an important process in early atherogenesis. C-peptide stimulated CD4(+) cell chemotaxis in a concentration-dependent manner. This process involves pertussis toxin-sensitive G-proteins as well as activation of phosphoinositide 3-kinase (PI 3-K). Biochemical analysis showed that C-peptide induced recruitment of PI 3-K to the cell membrane as well as PI 3-K activation in human CD4(+) cells. In addition, antidiabetic peroxisome proliferator-activated receptor gamma-activating thiazolidinediones inhibited C-peptide-induced CD4(+) cell chemotaxis as well as PI 3-Kgamma activation. Finally, immunofluorescence staining of thoracic artery specimen of diabetic patients showed intimal CD4(+) cells in areas with C-peptide deposition. Thus, C-peptide might deposit in the arterial intima in diabetic patients during early atherogenesis and subsequently attract CD4(+) cells to migrate into the vessel wall.

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Citations

Apr 7, 2010·Basic Research in Cardiology·Daniel WalcherNikolaus Marx
Jun 7, 2013·Current Atherosclerosis Reports·Corinna Lebherz, Nikolaus Marx
May 12, 2012·Journal of Biochemistry·Tatsuya IshiiKazuhiro Kimura
May 2, 2012·Mediators of Inflammation·Dusica Vasic, Daniel Walcher
Jul 5, 2012·International Journal of Inflammation·Dusica Vasic, Daniel Walcher
Apr 17, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jin-young Min, Kyoung-bok Min
Dec 29, 2011·Frontiers in Bioscience (Scholar Edition)·Meghana PansuriaHong Wang
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·James D ChangLewis C Cantley
Dec 29, 2010·Mediators of Inflammation·Thomas WalcherDaniel Walcher
Apr 7, 2009·Seminars in Immunopathology·Daniel Walcher, Nikolaus Marx
May 25, 2010·Cellular and Molecular Life Sciences : CMLS·Nikolaus MarxDaniel Walcher
Mar 1, 2008·Trends in Cardiovascular Medicine·Nikolaus Marx
Aug 2, 2007·The American Journal of Cardiology·Amy Stancoven, Darren K McGuire
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Dec 7, 2010·Pediatric Diabetes·Patrizia LuppiJohn Wahren
Jun 29, 2011·Journal of Cellular and Molecular Medicine·Dusica VasicDaniel Walcher
Sep 5, 2006·The American Journal of Cardiology·Vincent E FriedewaldWilliam C Roberts
Mar 19, 2015·Rheumatology International·Mathias BurgmaierVincent Brandenburg
Apr 3, 2008·Experimental Diabetes Research·Claire E Hills, Nigel J Brunskill
Nov 26, 2010·Biochemical and Biophysical Research Communications·Charlotte NereliusHans Jörnvall
Nov 24, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Daniel Walcher, Nikolaus Marx
Jun 2, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Marina CardelliniMassimo Federici
Mar 6, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heather FrancisGianfranco Alpini
Aug 31, 2018·Diabetes/metabolism Research and Reviews·Michelle Teodoro AlvesKarina Braga Gomes
Feb 24, 2006·Endocrine Reviews·Julie NigroPeter J Little
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lina NordquistA Erik G Persson
Jul 3, 2015·Physiology·Gina L C Yosten, Grant R Kolar
Feb 27, 2009·Clinical Science·Claire E Hills, Nigel J Brunskill
Apr 4, 2021·Biomedicines·Rachel L WashburnJannette M Dufour

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