C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in cord serum of twins: genetic versus environmental regulation

American Journal of Obstetrics and Gynecology
J VerhaegheA M Schutter

Abstract

Our purpose was to examine the regulation of fetal serum concentrations of insulin (C-peptide), insulin-like growth factor-I, insulin-like growth factor-II, and insulin-like growth factor binding protein-1, which are growth-regulating factors in the fetus, in monozygotic and dizygotic twin pairs. Cord serum samples were collected from 110 twin pairs and compared with 178 nonsibling singleton pairs with the same gestational age. Five twin pairs were excluded from the statistical analyses because of severe intrauterine growth restriction and placental abnormalities in one. Zygosity was assigned by histologic examination of the placenta and by a questionnaire sent to the mother when the twins were > or = 6 months old. Analyses included the calculation of correlation coefficients, between-pair variation, and univariate genetic analysis. Cord serum C-peptide concentrations were highly correlated in monozygotic (r = 0.94) and dizygotic twins (r = 0.79) but not in singleton pairs (r = -0.05); the between-pair variation was also smaller in twins than in singletons. Genetic analysis demonstrated a large contribution of the common environment to the variance in C-peptide concentrations (80%) and a smaller genetic contribution (12%). Insu...Continue Reading

References

Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Jan 1, 1989·Behavior Genetics·R VlietinckM Thiery
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·A BennettR L Hintz
Dec 1, 1980·Diabetes·N Freinkel
Jul 1, 1995·British Journal of Obstetrics and Gynaecology·R A CrawfordT Chard
Sep 14, 1995·The New England Journal of Medicine·K E von Mühlendahl, H Herkenhoff
Mar 1, 1994·Behavior Genetics·M C NealeK S Kendler
Feb 1, 1994·The Journal of Clinical Endocrinology and Metabolism·P C KaoC A Lang
Jul 1, 1993·American Journal of Obstetrics and Gynecology·T H Hakala-Ala-PietiläM T Seppälä

❮ Previous
Next ❯

Citations

Feb 15, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Fuat Emre CanpolatMurat Yurdakok
Nov 17, 2010·Gynecologic Oncology·Monica McGrathImmaculata De Vivo
Mar 20, 2015·Clinical Epigenetics·Meriem OuniPierre Bougnères
Jan 4, 2015·Behavior Genetics·G Frederiek Estourgie-van BurkDorret I Boomsma
Apr 10, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Carolyn S P LamRamachandran S Vasan
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Mattias JohanssonRudolf Kaaks
Oct 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Jennifer StoneMitch Dowsett
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Jacqueline M MajorElizabeth Barrett-Connor
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Mattias JohanssonRudolf Kaaks
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·C J Rosen, J P Bilezikian
Mar 23, 2007·American Journal of Physiology. Cell Physiology·Maria Pia SperandeoGianfranco Sebastio
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James D McKayHenrik Grönberg
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Jun 10, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·W A Ester, A C S Hokken-Koelega

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.