PMID: 619224Jan 1, 1978

C-peptide secretion and insulin antibodies as determinants of stability in diabetes mellitus

Metabolism: Clinical and Experimental
D K YueJ R Turtle

Abstract

The relative significance of residual beta-cell secretory activity and human insulin antibodies in determining diabetic stability has been examined in 35 diabetic subjects. The response of plasma C-peptide immunoreactivity following 50 g oral glucose has been used as an index of beta-cell function. Glucose-stimulated C-peptide secretion was observed in 58% of stable diabetics, but in no labile diabetics. When present, C-peptide secretion following a glucose load in diabetics was of smaller amplitude and slower in onset, but more prolonged than in normal subjects. In secretors, stability of diabetes was significantly correlated with the magnitude of the C-peptide response. As a group, labile diabetics had lower insulin antibody levels than stable patients, but stability and antibody levels were not correlated in individual patients. In non-secretors there was no difference in antibody levels between the stable and labile groups. Neither the equilibrium binding affinities nor the dissociation rate constants differed significantly for antibodies from stable and labile diabetics. Thus stability of diabetes depends upon residual beta-cell secretory activity, but not on the concentration or binding characteristics of insulin antibodies.

References

Aug 24, 1976·Biochimica Et Biophysica Acta·D K YueJ R Turtle
Nov 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G FinkL Recant
May 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Prószyńska, B Sadowska
Sep 1, 1972·Metabolism: Clinical and Experimental·P J PalumboW N Tauxe
Jun 1, 1958·The Journal of Clinical Investigation·J H SKOM, D W TALMAGE
Nov 1, 1959·The Journal of Clinical Investigation·S A BERSON, R S YALOW

Citations

Oct 1, 1980·Diabetologia·A B Kurtz, J D Nabarro
Nov 1, 1979·Diabetologia·P McNairI Transbøl
Jan 1, 1981·Journal of Immunoassay·U KrauseJ Beyer
Jan 18, 1986·British Medical Journal·J Pickup
Jan 1, 1985·Postgraduate Medical Journal·S A Olczak, R H Greenwood
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Jun 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·H J GjessingA Frøland
Jul 25, 1981·British Medical Journal·A el-MakriH Ben Ayed
Feb 1, 1980·Australian and New Zealand Journal of Medicine·A McElduffK M Bowen
Feb 1, 1982·Australian and New Zealand Journal of Medicine·C GlatthaarE A Espiner
Apr 26, 2007·American Journal of Physiology. Endocrinology and Metabolism·Klara SjögrenKen K Y Ho
Jul 1, 1984·Scottish Medical Journal·R S GrayR A Elton
Jan 1, 1980·Journal of Endocrinological Investigation·D GiuglianoP J Lefebvre

Related Concepts

C-Peptide
Diabetes Mellitus
Intravenous Glucose Tolerance Test
Insulin Antibodies
Polypeptides

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