PMID: 350677Jun 1, 1978

C-peptide secretion during the remission phase of juvenile diabetes

E HeinzeE F Pfeiffer


C-peptide secretion was studied in eight juvenile diabetics during the remission phase of the disease. The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion. Under all conditions the intravenous glucose load had only a minimal effect on the secretion of C-peptide, while arginine alone or after the intravenous glucose tolerance test stimulated the release of the peptide in all patients. Pretreatment with glucose did not augment the effect of arginine on C-peptide release. The results indicate that during the remission phase of juvenile-onset diabetes the endocrine pancreas does not recognize glucose as and appropriate signal for C-peptide release and cannot transform the amplifying effect of glucose into a higher hormonal secretion rate.


Jan 1, 1981·Journal of Immunoassay·U KrauseJ Beyer
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·R S GrayB F Clarke
Mar 1, 1980·The Journal of Pediatrics·M MenchiniG Chiumello
Jul 1, 1979·Acta paediatrica Scandinavica·E HeinzeE Kleihauer
Jun 11, 1981·The New England Journal of Medicine·G F Cahill, H O McDevitt
Apr 30, 2003·Diabetes·Carla GreenbaumImmunology of Diabetes Society
Sep 1, 1991·Annals of Saudi Medicine·H Salman
Nov 1, 1979·Postgraduate Medicine·D E Melnick
Sep 8, 2019·The Journal of Pathology. Clinical Research·Peter SeironOlle Korsgren
Oct 31, 2017·Diabetes, Obesity & Metabolism·Oskar Skog, Olle Korsgren

Related Concepts

Arginine hydrochloride
Malignant Neoplasm of Endocrine Pancreas
Annular Pancreas
Remission, Spontaneous
Entire Endocrine Pancreas
Glucose Tolerance Test
Process of Secretion
Insulin C-peptide Measurement
Cancer Remission

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.