C-reactive protein and fibrinogen levels as determinants of recurrent preeclampsia: a prospective cohort study

Journal of Hypertension
Bas B van RijnArie Franx

Abstract

Women with a history of early-onset preeclampsia have an increased risk of recurrent preeclampsia and are more prone to develop future cardiovascular disease. At present, risk factors underlying this association are not well characterized. We investigated whether the risk of recurrent preeclampsia is associated with pre-pregnancy levels of common cardiovascular and inflammatory markers. Reproductive follow-up and cardiovascular parameters were obtained for 150 primiparae with a history of early-onset preeclampsia 6-12 months after their first delivery. Simultaneously, fasting plasma samples were collected and tested for lipids, glucose, C-reactive protein and fibrinogen. The relative contribution of each marker to the recurrence risk of preeclampsia and preterm delivery was estimated by Cox proportional hazard models. Forty-two women (28%) developed preeclampsia in a next pregnancy. Recurrent preeclampsia was related to elevated pre-pregnancy levels of C-reactive protein and fibrinogen when compared to women who did not develop recurrent disease. We found no associations between recurrent preeclampsia and maternal age, pre-pregnancy BMI, smoking or fasting levels of total cholesterol, high-density lipoprotein-cholesterol, low-d...Continue Reading

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Citations

Oct 15, 2014·Genetic Testing and Molecular Biomarkers·Yuting WangXu Ma
Dec 24, 2014·Climacteric : the Journal of the International Menopause Society·A CagnacciB Palmieri
Nov 5, 2015·Journal of Pathology and Translational Medicine·Joo-Yeon Kim, Yeon Mee Kim
Apr 27, 2018·Nursing Research·Kathleen Darrah Black, June Andrews Horowitz
Aug 18, 2016·Heart·Nathalie AugerGilles Paradis
Sep 13, 2017·European Journal of Preventive Cardiology·T Katrien J GroenhofA Titia Lely
Sep 26, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mamoru MorikawaHidemichi Watari
Dec 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Silvia GalbiatiMaddalena Smid
Jan 10, 2018·The Journal of Clinical Hypertension·Yong WangLing Chen

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