C-reactive protein and homocysteine are associated with dietary and behavioral risk factors for age-related macular degeneration

Nutrition
J M SeddonRoy C Milton

Abstract

We investigated whether age-related macular degeneration risk factors are associated with high-sensitivity C-reactive protein (CRP) and homocysteine (HCY), systemic biomarkers for cardiovascular disease. Subjects with a range of age-related macular maculopathies or no maculopathy at two centers in the United States were evaluated. Risk factors and biomarkers were assessed by questionnaire, direct measurement, or analyses of blood specimens. Higher levels of serum antioxidants vitamin C and lutein/zeaxanthin and higher fish intake were associated with lower serum CRP levels, whereas serum vitamin E, smoking, and increased body mass index were associated with increased CRP. Serum vitamin E, serum alpha-carotene, and dietary intake of antioxidants and vitamin B6 were associated with lower levels of plasma HCY, whereas hypertension was associated with increased HCY. C-reactive protein and HCY levels are related to traditional dietary and behavioral factors associated with age-related macular degeneration.

References

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Citations

Apr 24, 2007·International Ophthalmology Clinics·Fina C Barouch, Joan W Miller
Jan 1, 2014·Progress in Retinal and Eye Research·Lucia Sobrin, Johanna M Seddon
Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·P T JohnsonL V Johnson
Mar 25, 2014·Ocular Immunology and Inflammation·Jung Kee MinJe Moon Woo
Feb 8, 2014·Current Eye Research·Jianbo LiMin Xie
Apr 3, 2012·Progress in Retinal and Eye Research·Aize KijlstraTos T J M Berendschot
Mar 25, 2014·Survey of Ophthalmology·Giuseppe Querques, Eric H Souied
Oct 13, 2016·Korean Journal of Ophthalmology : KJO·Bengi Ece Kurtul, Pinar Altiaylik Ozer
Dec 15, 2016·Acta Ophthalmologica·Antonio PinnaGiuliana Solinas
Jan 30, 2018·European Journal of Clinical Investigation·Sayyed Saeid KhayyatzadehMajid Ghayour-Mobarhan
Oct 23, 2015·The American Journal of Clinical Nutrition·Bénédicte M J MerleJohanna M Seddon
Dec 23, 2016·American Journal of Physiology. Cell Physiology·Blanca MolinsJordi Martorell
May 15, 2020·Investigative Ophthalmology & Visual Science·Bénédicte M J MerleJohanna M Seddon
May 5, 2018·Frontiers in Immunology·Blanca MolinsAndrew D Dick
Dec 9, 2020·Asia-Pacific Journal of Ophthalmology·Martine J Jager, Johanna M Seddon
Dec 29, 2020·Translational Vision Science & Technology·Cailey WeaverJuan Pablo de Rivero Vaccari
May 11, 2021·Critical Reviews in Food Science and Nutrition·Kristin KruegerMarietta Zille
Apr 11, 2008·Journal français d'ophtalmologie·V BiousseA Gaudric

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