C-reactive protein and the acute phase reaction in geriatric patients

Zeitschrift für Gerontologie und Geriatrie
Thomas BertschHans Jürgen Heppner

Abstract

The C-reactive protein (CRP), first described as a serum component capable of precipitating the C-polysaccharide of pneumococci, is one of the most important proteins because the serum concentration rises in the acute phase reaction. The acute phase reaction is the nonspecific reaction of the body to noxious stimuli of the most varied kinds, such as infections, burns, neoplasms and tissue trauma. The CRP is synthesized in liver parenchymal cells by cytokines which are derived from stimulated leucocytes and released into the circulation. Because of its molecular structure and in synergy with the complement system, it is able to precipitate and/or lyse microorganisms, thereby rendering them harmless. Measurement of the serum CRP concentration can provide important information with respect to the diagnosis and monitoring of treatment. Due to immunosenescence in geriatric patients the synthesis of CRP appears to be limited to inflammatory stimuli; however, this phenomenon does not appear to be of major clinical relevance. Despite the introduction of new parameters of the acute phase reaction, sometimes with better performance, such as interleukin-6, procalcitonin and the soluble endotoxin receptor sCD14, measurement of CRP for diag...Continue Reading

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Citations

Sep 7, 2016·European Journal of Internal Medicine·Andrea TicinesiTiziana Meschi
Oct 1, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jan MácaMichal Holub
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Sep 9, 2018·Acta Neuropathologica Communications·Sonja RakicDelphine Boche

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