PMID: 22574550May 12, 2012Paper

C-reactive protein as a monitor of chemotherapy response in advanced non-small cell lung cancer (CML study)

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Vichien SrimuninnimitNopadol Soparattanapaisarn

Abstract

The aim of the present prospective study was to evaluate the correlation between the change of serum c-reactive protein (CRP) levels and response to chemotherapy in patients with locally advanced or metastatic non-small cell lung cancer. Patients with locally advanced or metastatic non-small cell lung cancer who received the first line chemotherapy were measured serum CRP levels prior to treatment. Chemotherapy regimen was given to patients according to physicians and radiologic imaging was evaluated after two or three cycles of treatment. Serum CRP levels were measured first time at pre-treatment and second time in patients who had pre-treatment serum CRP levels greater than normal range (3 mg/l) at the time of response assessment or clinical progression. The primary endpoint was the correlation between change of serum CRP levels and radiologic response. The secondary endpoint was the prevalence of elevated CRP levels in advanced NSCLC patients and correlation between initial CRP levels and progression free survival (PFS). Fifty four patients were enrolled. Prevalence of elevated CRP levels in advanced NSCLC was 76%. Thirty patients had serial serum CRP measured. There was correlation between change in serum CRP levels and res...Continue Reading

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