C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study

British Journal of Anaesthesia
N Al-SubaieG M Hall

Abstract

Recent studies have found plasma C-reactive protein (CRP) to be a predictor of outcome after discharge from the intensive care unit (ICU). To assess the generalizability of this finding, we assessed the value of CRP on the day of ICU discharge as a predictor of unplanned ICU readmission and unexpected death within 2 weeks. Plasma albumin and white cell count at discharge were also considered as markers associated with ongoing inflammation. This was a single-centre observational study involving a medical-surgical ICU in a university teaching hospital. Data were prospectively collected from 1487 admissions involving 1401 patients over a 12 month period. Patients' admission details and APACHE II score were collected in addition to plasma CRP, white cell count, and albumin values from the day of discharge from ICU. We assessed the difference in these variables between patients who were readmitted, who died unexpectedly, and those who did not. We found that 9.9% of patients discharged were either readmitted (7.0%) or died unexpectedly (2.9%). Patients who were readmitted had a lower plasma albumin concentration [20 (16, 24) vs 22 (19, 27), P<0.001] and a higher admission APACHE II score [median (inter-quartile range, IQR) 16.5 (13, ...Continue Reading

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Citations

Apr 30, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Wilhelm GranderMartin Dünser
Mar 17, 2012·Current Opinion in Infectious Diseases·Christoph LichtensternMarkus A Weigand
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