C-reactive protein as a prognostic risk factor for loss of arteriovenous fistula patency in hemodialyzed patients

Journal of Vascular Surgery
Oana StirbuMircea Calin Tandrau

Abstract

Inflammation is a cardiovascular risk factor in hemodialysis patients, but its influence on vascular access patency is still debatable. Our prospective study investigated this issue. A total of 258 patients receiving an arteriovenous fistula (AVF) between 2006 and 2016 at the Municipal Hospital Arad were included. Demographic, clinical, and laboratory characteristics were collected at the time of creation of the AVF. The primary study end point was AVF patency loss, defined as an event occurring at least 2 months after AVF formation and requiring surgical revision or replacement of the fistula. The patients were followed up for a median time of 26 months. In our group, the mean age was 59.7 ± 13.2 years (median, 62 years), and 60.1% were male. During follow-up, 134 patients (51.9%) maintained AVF patency, whereas 124 (48.1%) lost AVF patency within a mean time of 23.3 ± 28.1 months (median, 10.5 months). We found that age (hazard ratio [HR], 1.015; P = .035) and C-reactive protein (CRP) level (HR, 1.17; P < .0001) were associated with a higher risk of loss of AVF patency. The protective factors for AVF patency were autosomal dominant polycystic kidney disease (HR, 0.336; P = .009), pre-emptive AVF (HR, 0.648; P = .031), and hig...Continue Reading

References

Apr 1, 1996·Journal of the American Society of Nephrology : JASN·H I FeldmanA Wasserstein
Mar 6, 2002·Journal of Vascular Surgery·Anton N SidawyK Craig Kent
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christoph Wanner, Thomas Metzger
Aug 28, 2004·American Journal of Nephrology·Gunnar H HeineMatthias Girndt
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Prabir Roy-ChaudhuryAlfred K Cheung
Apr 8, 2006·Blood Purification·Che-Yi ChouChiu-Ching Huang
Feb 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mahmut Ilker YilmazPeter Stenvinkel
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Juan Jesús Carrero, Peter Stenvinkel
Aug 27, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan BazeleyBruce M Robinson
Aug 3, 2013·Renal Failure·Mehmet Ali KayginBilgehan Erkut
Nov 5, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ahmed A Al-JaishiLouise M Moist
Oct 1, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tanushree BanerjeeNeil R Powe
Feb 11, 2015·Blood Purification·Oleh M Akchurin, Frederick Kaskel
Jun 26, 2015·The Journal of Vascular Access·Ramon Roca-TeyUNKNOWN Catalan Renal Registry Committee
Jan 23, 2016·Clinical Kidney Journal·Agnes MasenguJennifer B Hanko
Jun 13, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N C Tanner, A F da Silva
Jun 28, 2016·Journal of Vascular Surgery·Jehad AlmasriM Hassan Murad
Oct 27, 2016·American Journal of Nephrology·Tsung-Yan ChenChih-Cheng Wu
Dec 27, 2016·Kidney International·Jair Munoz MendozaUNKNOWN CRIC Study Investigators
Apr 28, 2017·Journal of Clinical Laboratory Analysis·Wei-Hung KuoChien-Te Lee
Aug 28, 2017·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L C BylsmaJ H Lawson
Nov 14, 2017·Hemodialysis International·Radojica V StolicJavorka S Mitic
Apr 1, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mae ThamerTimothy A Pflederer

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Citations

Jan 22, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Yutaka Matsubara (松原裕)Alan Dardik
Jan 1, 2020·Journal of Vascular Surgery. Vascular Science·Yutaka MatsubaraAlan Dardik
Jul 31, 2021·The Journal of Vascular Access·Ramon Roca-TeyJordi Calls

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