C-Reactive protein, clinical outcome, and restenosis rates after implantation of different drug-eluting stents

The American Journal of Cardiology
Achille GaspardoneOlga Skossyreva

Abstract

Sirolimus-eluting stents (SESs), paclitaxel-eluting stents (PESs), and dexamethasone-eluting stents (DEXs) have anti-inflammatory properties; thus, the decreased in-segment restenosis rate observed with the use of these stents might be related to a weaker postprocedural inflammatory response. One hundred sixty consecutive patients with stable coronary artery disease who underwent successful single-vessel/lesion coronary artery stenting were prospectively studied. Thin-strut bare metal stents were deployed in 39 patients, SESs in 30, PESs in 61, and DEXs in 30. The 4 groups were similar with respect to demographic and angiographic variables and prevalence of risk factors. C-reactive protein (CRP) was measured at baseline and 24 and 48 hours after the procedure. Maximal increase in CRP was calculated as the increase in CRP at 48 hours/CRP compared with baseline. Angiographic follow-up was performed after 12.9 +/- 1.3 months or sooner, if needed, on the basis of clinical evidence. All patients presented a postprocedural increase in CRP that peaked at 48 hours (median 10.0 mg/L). Maximal CRP increase was similar across the 4 groups (medians 3.5 mg/L in the bare metal stent group, 3.6 mg/L in the SES group, 4.0 mg/L in the PES group...Continue Reading

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Citations

Mar 17, 2010·Future Cardiology·Rocco Antonio MontoneGiampaolo Niccoli
Jul 24, 2012·The Canadian Journal of Cardiology·Rami N KhouzamUzoma N Ibebuogu
Aug 8, 2007·Journal of Interventional Cardiology·Natale Daniele BrunettiMatteo Di Biase
Oct 24, 2006·The American Journal of Cardiology·Atul Aggarwal
Nov 20, 2010·Journal of the American College of Cardiology·Giampaolo NiccoliFilippo Crea
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Santiago Jimenez-ValeroJose López-Sendón
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